Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Blood Type of connective tissue The only fluid tissue in the human body 38 degrees celsius or degrees farenheit Slightly alkaline, pH About 5x’s thicker than water 5.3 Q average adult More blood in males than females Account for approximately 8% of body weight
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functions: Transport, Regulation and Protection The transport functions include: carrying oxygen and nutrients to the cells. transporting carbon dioxide to the lungs (for removal) transporting nitrogenous wastes to the kidneys (for removal) carrying hormones from the endocrine glands to the target tissues. The regulation functions include: removing heat from active areas, such as skeletal muscles, and transporting it to other regions or to the skin where it can be dissipated (maintaining body temp) pH regulation through the action of buffers in the blood. The protection functions include: preventing fluid loss by forming clots protect the body against microorganisms that cause disease
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings 2 Parts of Whole Blood 1.Cells (formed elements) living component 45% of total blood 3 main types formed in red bone marrow of long bones, some in other organs as needed 2.Plasma (matrix) non-living component 55% of total blood mainly water (90%) over 100 dissolved substances ex. nutrients, salts (electrolytes), gases, hormones, proteins, carbs, amino acids, vitamins, carbon dioxide, urea, ammonia
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings 2. Plasma (matrix) non-living component 55% of total blood mainly water (90%) over 100 dissolved substances ex. nutrients, salts (electrolytes), gases, hormones, proteins, carbs, amino acids, vitamins, carbon dioxide, urea, ammonia Plasma proteins Most abundant solutes in plasma Most are made by the liver Ex. Albumin—regulates osmotic pressure and thickens blood Clotting proteins—help when a blood vessel is injured
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Separating Blood Components Layers are based on density Plasma rises to the top Thin white middle layer: Buffy coat: contains white blood cells (leukocytes) and platelets) Red Blood Cells: Erythrocytes: sink to the bottom (% is known as the hematocrit) Red Blood Cells
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings 2 Main Formed Elements (Blood Cells) Erythrocytes Red blood cells (RBCs) Leukocytes White blood cells (WBCs) Platelets Cell fragments and not whole cells, necessary for blood clotting
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings All formed elements stem from a specific type of cell Lost cells are replaced by division of hemocytoblasts (blood stem cells) in the red bone marrow
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings 1. Erythrocytes Commonly known as red blood cells or RBCs Main function is to carry oxygen Anatomy of circulating erythrocytes Biconcave disks Essentially bags of hemoglobin Anucleate (no nucleus) Contain very few organelles *4-6 million RBCs per cubic millimeter of blood
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Formation of Erythrocytes Unable to divide, grow, or synthesize proteins Wear out in 100 to 120 days RBCs are eliminated by phagocytes in the spleen or liver
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Hemoglobin Iron-containing protein Binds strongly, but reversibly, to oxygen Each hemoglobin molecule has four oxygen binding sites Each erythrocyte has 250 million hemoglobin molecules Hemoglobin is recycled in the body *Normal blood contains 12–18 g of hemoglobin per 100 mL blood
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings 2. Leukocytes commonly known as white blood cells or WBCs Crucial in the body’s defense against disease These are complete cells, with a nucleus and organelles Able to move into and out of blood vessels Respond to chemicals released by damaged tissues Many types of WBC’s some are macrophages and some produce antibodies or histamine *4,000 to 11,000 WBC per cubic millimeter of blood
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Formed Elements Types of leukocytes Granulocytes Granules in their cytoplasm can be stained Possess lobed nuclei Include neutrophils, eosinophils, and basophils Agranulocytes Lack visible cytoplasmic granules Nuclei are spherical, oval, or kidney- shaped Include lymphocytes and monocytes
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Formed Elements List of the WBCs from most to least abundant Neutrophils Lymphocytes Monocytes Eosinophils Basophils Types will vary depending on a persons health at the time Easy way to remember this list Never Let Monkeys Eat Bananas
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Neutrophils Multilobed nucleus with fine granules Act as phagocytes at active sites of infection Eosinophils Large brick-red cytoplasmic granules Found in response to allergies and/or parasitic worms Types of granulocytes
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Basophils Have histamine-containing granules Initiate inflammation
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Types of agranulocytes Lymphocytes Nucleus fills most of the cell B-lymphocytes produce antibodies —collect and clump bacteria together, easier for phagocytes to “eat” them T-lymphocytes directly attack cells that do not belong (cell tag receptor incorrect) Monocytes Largest of the white blood cells Function as macrophages Important in fighting chronic infection
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings 3. Platelets Derived from ruptured multinucleate cells (megakaryocytes) Needed for the clotting process Normal platelet count = 300,000/mm 3