Orthopedics Inflammatory Process Jan Bazner-Chandler RN, MSN, CNS, CPNP
Inflammatory Process Osteomyelitis Septic arthritis Juvenile arthritis
Osteomyelitis Webmd.lycos.com
Osteomyelitis Infection of bone and tissue around bone. Requires immediate treatment Can cause massive bone destruction and life-threatening sepsis
Pathogenesis of Acute Osteo Under 1 year the epiphysis is nourished by arteries. In children 1 year to 15 years the infection is restricted to below the epiphysis.
Clinical Manifestation Localized pain Decreased movement of area With spread of infection Redness Swelling Warm to touch
Diagnostic Tests: X-ray CBC ESR / erythrocyte sedimentation rate C-reactive protein Bone scan – most definitive test for osteomyelitis
X-Ray 18-year-old boy with painful right arm
Osteomyelitis
Management Culture of the blood Aspiration at site of infection Intravenous antibiotics x 4 weeks PO antibiotics if ESR rate going down Monitor ESR Decrease in levels indicates improvement
Goals of Care To maintain integrity of infected joint / joints
Septic Arthritis Infection within a joint or synovial membrane Infection transmitted by: Bloodstream Penetrating wound Foreign body in joint
Septic Arthritis of Hip Difficulty walking and fever Diagnosis: x-ray, ESR, aspiration of fluid from joint
Septic Hip Flexed hip on affected side is common presentation.
Diagnostic Tests X-ray Needle aspiration under fluoroscopy
Erythrocyte Sedimentation Rate ESR Used as a gauge for determining the progress of an inflammatory disease. Rises within 24 hours after onset of symptoms. Men: mm./hr Women:0 – 20 mm./hr Children:0 – 10 mm./hr
C-Reactive Protein During the course of an inflammatory process an abnormal specific protein, CRP, appears in the blood. The presence of the protein can be detected within 6 hours of triggering stimulus. More sensitive than ESR / more expensive
Joint Space Fluid WBC80,000 Segs88% Monos1% Lymphs11% RBC16,000 Gram StainGram-positive cocci in chains
Management Administration of antibiotics for 4 to 6 weeks. Oral antibiotics have been found to be effective if serum bactericidal levels are adequate. Fever control Ibuprofen for anti-inflammatory effect
Juvenile Rheumatoid Arthritis Chronic inflammatory condition of the joints and surrounding tissues. Often triggered by a viral illness 1 in 1000 children will develop JRA Higher incidence in girls
Clinical Manifestations Swelling or effusion of one or more joints Limited ROM Warmth Tenderness Pain with movement
Diagnostic Evaluation Elevated ESR / erythrocyte sedimentation rate + genetic marker / HLA b27 + RF 9 antinuclear antibodies Bone scan MRI Arthroscopic exam
Goals of Therapy To prevent deformities To keep discomfort to a minimum To preserve ability to do ADL
Management First line drugs: ASA NSAIDs Immunosuppressive drugs (oral): azulvadine or methotrexate Disease modifying drugs Enbrel - IM Remicade - IV
ASA Therapy Alert: The use of aspirin has been highly associated with the development of Reye’s syndrome in children who have had chickenpox or flu. Because aspirin may be an an ongoing p art of the regimen of the arthritic child, parents should be warned of the relationship between viral illnesses an aspirin, and be taught the symptoms of Reye’s syndrome.
Management Physical therapy Exercise program Monitor ESR levels Regular eye exams: Iriditis Cardiac involvement: early studies show some correlation due to inflammatory process
Iriditis Intraocular inflammation of iris and ciliary body 2% to 21% in children with arthritis Highest incidence in children with multi joint involvement disease.
Clinical Manifestations Deep eye pain Photophobia Often report decrease in color perception Redness no drainage Treatment: prednisone eye drops or PO prednisone
Muscular Dystrophy A group of more than 30 genetic diseases characterized by progressive weakness and degeneration of the skeletal muscles that control movement.
Duchenne Most common form of MD and primarily affects boys. Caused by absence of dystophin a protein needed to maintain integrity of muscle. Onset between 3 and 5 years Rapid progression: unable to walk by age 12.
Treatment No cure Physical therapy Respiratory therapy Speech therapy Orthopedic appliances / corrective procedures Meds: corticosteroids and immununosuppressants to slow progression of the disease.