Smart solutions for faster product and process innovation InsightFaraday  A New Approach to Boosting R&D Productivity

Smart solutions for faster product and process innovation Our Purpose To promote the development and exploitation of high throughput technologies (HTT) to enable increased R&D productivity  Leaner laboratory processes  Efficient use of valuable R&D resource  Faster Innovation

Smart solutions for faster product and process innovation  Office in Runcorn, Cheshire  Core partner is LGC  Customers include: The Operation Universities HTT user companies Chemical, Agrochem, Pharmaceutical, Home & Personal Care, Biotech, R&D service providers... HTT suppliers

Smart solutions for faster product and process innovation Lean Lab ?

Smart solutions for faster product and process innovation High Throughput Lab How ? How Much ? £ £ £ $ $ $ € € €

Smart solutions for faster product and process innovation High Throughput Technologies Tools for boosting R&D productivity Software DoE in-silico simulation LIMS Control Mass data handling Data mining Multivariate statistics Data visualisation Hardware Robots Electronics Parallel (micro)reactors Precision dosing Measurement devices Storage systems Tags & readers Bespoke automation  Interdisciplinary  Disruptive

Smart solutions for faster product and process innovation LabSmart Laboratory Audit Service  Facilitating the use of HTT  Capitalising on Investment  Maximising Cost Benefit …boosting R&D productivity

Smart solutions for faster product and process innovation Insight’s Laboratory Audit Produce figures for improved R&D productivity Convince senior management to invest in HTT

Smart solutions for faster product and process innovation Step 1Map the laboratory work flow  identify unit operations and resources Step 2Run the LabSmart™ model - validate for current data  calculate sample throughput  monitor resource utilisation  identify bottle neck operations Step 3Identify options for increasing throughput Step 4Model “high-throughput” scenarios  Find optimum solution (cost & throughput) The Audit Process

Smart solutions for faster product and process innovation A Laboratory Case Study (LGC POET team)

Smart solutions for faster product and process innovation Situation September 2003 Good Sample numbers increasing rapidly Bad  Turnaround times were increasing  Costs were increasing  Internal delivery conflicts  Erosion of quality  Customer dissatisfaction Danger of losing the contract

Smart solutions for faster product and process innovation Approach  New Management structure  First team to undergo LabSmart Audit  Concentrated on: >work flows >data transfers >sample preparation >analytical methods (repeat rates, time, cost) >logistics >customer needs

Smart solutions for faster product and process innovation Improvement Plan Aims: Reduce turnaround times Eliminate backlog Return to profit

Smart solutions for faster product and process innovation Original Laboratory

Smart solutions for faster product and process innovation Optimised Laboratory

Smart solutions for faster product and process innovation Operational Improvements  Laboratory space -60m 2 (1.5 modules)  Turnaround times 5-10 from >60 days  Capacity Doubled (>200 p/m)  Backlog From over 250 to Nil  40% reduction in staff costs (13.5 to 8.5 FTE)  Leaner, cheaper processes

Smart solutions for faster product and process innovation Analytical Improvements  Data transfers reduced by 70%  All instruments running on same data acquisition system  Sample preparation time cut  Faster analytical methods  Sample volume required cut by 80%  LIMS automated invoicing  Higher reproducibility & improved quality

Smart solutions for faster product and process innovation Result  Payback in 4 Months  Increased Customer Satisfaction  Increased Employee Satisfaction

Smart solutions for faster product and process innovation Application Areas Sector - specialty chemicals - home & personal care - life sciences - materials - …. Applications - formulation - synthesis - measurement - process development - …. Technology - new platforms - physical measurement - data handling - modelling - …. What can HTT do for you?