Cortical vs. subcortical loops. Lateral inhibition in striatum.

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Presentation transcript:

Cortical vs. subcortical loops

Lateral inhibition in striatum

Switching from one action to another

Direct and indirect pathways

Hyperdirect pathway

Lesions that cause hemiballism

Direct pathway

Indirect pathways

Loops through the basal ganglia Circuit nameBasal ganglia regions: Connected with:Functions to control: SkeletomotorPutamen; GPi, and SNpr VL/VA; motor cortex, prefrontal cortex Actions OculomotorBody of the caudate, SNpr Intralaminar nuclei, MD, VA; frontal and parietal eye fields; superior colliculus Gaze and orienting movements Dorsolateral prefrontal Head of the caudate, GPi and SNpr VA, VL and MD;Executive function, strategic planning OrbitofrontalCaudate, SNpr, ventral pallidum MD; orbitofrontal cortexMotivation, ability to play well with others Anterior cingulate aka limbic Ventral striatum, ventral pallidum MD; anterior cingulumEmotionality, motivated behavior