Biology for Future Presidents Important Concepts That Can Be Easily Understood Unless noted, the course materials are licensed under Creative Commons Attribution- NonCommercial-ShareAlike 2.5 Taiwan (CC BY-NC-SA 2.5)Attribution- NonCommercial-ShareAlike 2.5 Taiwan by Professor Larry N. Vanderhoef Chancellor Emeritus & Distinguished Professor University of California, Davis, U.S.A Stem Cells – Simple Biology, Moral Dilemma Week9 Design courtesy of fppt.com

Stem Cells Wikispace Human Physiology 2

Cell Fate Tree biochemj.org / Stem cells in the adult pancreas and liver, Biochemical Journal (2007) Volume 404, Diagram of stem cell division and differentiation. A - stem cell; B - progenitor cell; C - differentiated cell; 1 - symmetric stem cell division; 2 - asymmetric stem cell division; 3 - progenitor division; 4 - terminal differentiation Stem cells are capable of maintaining the stem cell compartment through self-renewal and can also give rise to progenitor cells that may undergo subsequent differentiation along more than one lineage to generate cell-type-specific derivatives. 3

Stem Cells Only the genes that a nerve cell needs continue to be “turned on” in nerve cells hESC Only the genes that a liver cell needs continue to be “turned on” in liver cells etc. 4

Stem Cells Bright Nepenthe / Marzie 5

Stem Cells In Vitro Fertilization Female Male hormones Many Eggs sperm Mix the eggs and sperm in a petri dish Extras are saved in Several put back in the Liquid nitrogen womb (uterus) to ensure success (hence, frequent multiple births) 6

Stem Cells anh-usa.org 7

Stem Cells Thursday, Nov. 11, 2010 Lab-Grown Lungs By Alice Park Growing new body parts has always been more science fiction than science reality, but that balance may quickly be shifting, at least in the lab. Relying on more sophisticated biosimulators that can better mimic body conditions, researchers have re-created the delicate architecture of a rat lung accurately enough for it to assume 95% of a normal lung's inhaling and exhaling functions. The key to their respiratory success was starting with a skeletal rat-lung template, including a matrix of blood vessels and collagen and other connective tissue, then seeding it with stem cells and nutrients to generate lifelike tissue that exchanged oxygen and carbon dioxide just like normal lung tissue. The ultimate goal is to replicate the feat on a larger scale: to replace enough human lung tissue to aid patients with emphysema or lung cancer. Read more: _ _ ,00.html _ _ ,00.html Source: TIME by Alice Park Thursday, Nov. 11,

Stem Cells Monday, September 20, 2010 University of California Office of the President “The University of California believes it is imperative that the scientific community be permitted to move forward with embryonic stem cell research that provides hope to millions of patients and their families.” 9

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WorkLicenseAuthor/Source This work is from TIME by Alice Park Thursday, Nov. 11, 2010, and used/modified subject to the fair use doctrine in accordance with: Taiwan Copyright Act Articles 52 & 65 The "Code of Best Practices in Fair Use for OpenCourseWare 2009 ( by A Committee of Practitioners of OpenCourseWare in the U.S. The contents are based on Section 107 of the 1976 U.S. Copyright Act. Wikipedia: Author Unknown /06/26 visited Page1. – 11. This work is from Outsource PowerPoint Template Free Powerpoint Templates+ GET uses this work subject to fair use doctrine for educational purpose only in based on its ABOUT: and Articles 52 & 65 of Taiwan Copyright Act. Copyright Declaration 11