Supplementary Figure 1 Mdm4 Mdm2 ATM p300 CBP HAUSP pRB p53 CDK4

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Supplementary Figure 1 Mdm4 Mdm2 ATM p300 CBP HAUSP pRB p53 CDK4 11: MDA-MB-134VI 13: MDA-MB-175VII 12: MDA-MB-157 14: MDA-MB-231 15: MDA-MB-330 16: MDA-MB-361 17: MDA-MB-415 18: MDA-MB-435S 19: MDA-MB-436 20: MDA-MB-453 21: MDA-MB-468 34: SUM225CWN 36: SUM1315M02 8: HCC1937 22: MPE600 23B: OCUB-M 24: SK-BR-3 25: SK-BR-5 26: SK-BR-7 27: SUM44PE 28: SUM52PE 30: SUM149PT 31: SUM159PT 32: SUM185PE 33: SUM190PT 35: SUM229PE 38: UACC-812 39: UACC-893 41: ZR75-30 1: BT20 2: BT474 4: BT549 5: CAMA-1 6: DU4475 7: EVSA-T 9: Hs578T 10: MCF-7 37: T47D 40: ZR75-1 Mdm4 Mdm2 ATM p300 CBP HAUSP pRB p53 CDK4 Cyclin D1 PUMA p21 p16 p14ARF Tubulin Tropomysosin Supplementary Figure 1

Supplementary Figure 2 A B *** *** ** *** *** *** *** *** *** *** ** C D *** * ** *** * *** *** *** * *** ** *** *** *** Supplementary Figure 2

A B C D Supplementary Figure 3

Supplementary Figure 4 + 10 µM Nutlin-3 Doxorubicin Mdm2 Mdm4 pSer15-p53 pSer46-p53 p53 PUMA p21 HAUSP Supplementary Figure 4