1. Supplementary data d a c d ab b Figure S1. Quantification of the Western blot data in figure 4C. The area density of each band was measured with a UVP gel document system. The data were normalized with β-tubulin and presented as ratio relative to the area density of β- tubulin. Bars represent means ± SEM. Bars with the same letters are not significantly different from each other (p>0.05). b cd d c a a b c c c a a b d c d a a b a c d d a

2. Supplementary data Figure S2. Quantification of the Western blot data in figure 5C. The area density of each band was measured with a UVP gel document system. The data were normalized with β-tubulin and presented as ratio relative to the area density of β- tubulin. Bars represent means ± SEM. Bars with the same letters are not significantly different from each other (p>0.05). c ab a a bc ab a a a b c b b b b aa a b d c a a a a a d b e c

3. Supplementary data Figure S3. Quantification of the Western blot data in figure 6A. The area density of each band was measured with a UVP gel document system. The data were normalized with β-tubulin and presented as ratio relative to the area density of β- tubulin. Bars represent means ± SEM. Bars with the same letters are not significantly different from each other (p>0.05). b d c cd a a b c c c a a b d c d a a c b d d bc a b d c d a a b c b c a a

4. Supplementary data Figure S4. Quantification of the Western blot data in figure 6B. The area density of each band was measured with a UVP gel document system. The data were normalized with β-tubulin and presented as ratio relative to the area density of β- tubulin. Bars represent means ± SEM. Bars with the same letters are not significantly different from each other (p>0.05). b d c d a a b b b b a a c d d a ab b b d c e f a b d c aa a b d c d d a