Curcumin Extreme™ Julian Blumenfeld, MD Chief Medical Officer Market America & nutraMetrix Curcumin Extreme™ Code: and 13145NM

Curcumin (BCM-95 ® ): 400 mg Broccoli Seed Extract (6% Glucosinolates): 167 mg Selenium (Selenomethionine): 100 mcg Curcumin Extreme™

Curcumin Turmeric root extract 3 major curcuminoids Curcumin Demethoxycurcumin Bis-demethoxycurcumin

Powerful antioxidant Promotes normal activity of NF-kappaB Promotes normal cell cycle activity, normal cellular regeneration Promotes neurological health, helps to maintain neurological health as we age Curcumin: Biological Activities Reduces superoxide anions Reduces peroxides Inhibits LDL oxidation and lipid peroxidation

Powerful antioxidant Promotes normal activity of NF-kappaB Promotes normal cell cycle activity, normal cellular regeneration Promotes neurological health, helps to maintain neurological health as we age Curcumin: Biological Activities In unhealthy cells, curcumin has been shown to interfere with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E) and apoptosis. -Anand, P., et al. Curcumin and cancer: an “old-age” disease with an “age-old” solution. Cancer Letters. 267: , 2008.

Curcumin: Biological Activities

Powerful antioxidant Promotes normal activity of NF-kappaB Promotes normal cell cycle activity, normal cellular regeneration Promotes neurological health, helps to maintain neurological health as we age Curcumin: Biological Activities Curcumin can cross the blood-brain barrier and bind directly to amyloid plaques and increase the uptake of amyloid-β protein by macrophages. -Zhang, L., et al. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer’s disease patients. Journal of Alzheimer’s Disease. 10: 1-7, 2006.

Curcumin: The BCM-95 ® Difference

Broccoli Seed Extract (6% Glucosinolates) Promotes the normal production of detoxification enzymes Helps maintain healthy glutathione levels Promotes apoptosis in unhealthy cells Promotes a strong immune system keap1m keap1c S H S H H S H S ARE nrf2 Nucleus Cytosol GST’s, GR, GPx, HO-1

Promotes the normal production of detoxification enzymes Helps maintain healthy glutathione levels Promotes apoptosis in unhealthy cells Promotes a strong immune system –Enhance total white blood cell count –Enhance phagocytic activity –Reduced elevated TNFα from LPS stimulated macrophages Broccoli Seed Extract (6% Glucosinolates) - Thejass, P. and Kuttan, G. Immunomodulatory activity of sulforaphane, a naturally occuring isothiocyanate from broccoli (Brassica oleracea). Phytomedicine. 14: , 2006.

Selenium (Selenomethionine) Required cofactor for selenoproteins –Glutathione peroxidase enzymes –Iodothyronine deiodinase enzymes Thyroxine (T4)Thyroid Hormone (T3) -Brown, K. and Arthur, J. Selenium, selenoproteins and human health: a review. Public Health Nutrition. 4: , OO HH Glutathione H H H H

Directions: Take one capsule per day, with or without a meal. Warning: If you are currently taking warfarin (Coumadin) or other anti-platelet/anti-coagulant medications, you should not take this product. If you are taking any other prescription drugs or have an ongoing medical condition, you should consult your physician before using this product. Women who are pregnant or nursing should not take this product. Curcumin Extreme™

Summary –Curcumin (BCM-95 ® ): 400 mg –Broccoli Seed Extract (6% Glucosinolates): 167 mg –Selenium (Selenomethionine): 100 mcg Why curcumin? Why now? Who would benefit? Curcumin Extreme™ Code: and 13145NM DC: $28.50 SR: $39.95 BV: 23