your partner in sophisticated organic chemistry Company profile

DyStar – Aliachem meeting 2 Where you can find us your partner in sophisticated organic chemistry

DyStar – Aliachem meeting 3 VUOS ownership your partner in sophisticated organic chemistry AGROFERT HOLDING,a.s.. SYNTESIA, a.s. VÝZKUMNÝ ÚSTAV ORGANICKÝCH SYNTÉZ a.s. (VUOS 100%

DyStar – Aliachem meeting 4 History Foundation of Research Laboratories Voucher Privatisation New name – VUOS Affiliation of Synthesia´s R&D 100% daughter company of Synthesia a.s. prepared for the sale

DyStar – Aliachem meeting 5 VUOS main businesses 1.R&D and Production of Fine chemicals 2.Toxicology and analytics your partner in sofisticated organic chemistry Emloyees in %Sales in %

DyStar – Aliachem meeting 6 The Certificates of VUOS ISO 9001:2001 Certificate of Good Laboratory Practice Certificate of Accreditation for Certification of Products No. 229/2002 Certificate of Accreditation No. 230/2002 Testing Laboratory No Certificate on Compliance with Principles of Good Laboratory Practice Certificate on Compliance with Principles of Good Manufacturing Practice in laboratory your partner in sofisticated organic chemistry

DyStar – Aliachem meeting 7 your partner in sofisticated organic chemistry Education structure of employees VUOS is located in area of long-lasting. chemical tradition with complete infrastructure Cooperation with University of Pardubice Strong Points

DyStar – Aliachem meeting 8 Research & Development pharmaceutical intermediates intermediates for microelectronics custom syntheses of chemical specialities dyes and pigments for special application your partner in sofisticated organic chemistry

DyStar – Aliachem meeting 9 Fine Chemicals Production Wide range of quantities Grams – in laboratory Kilograms – in kilolab unit Metric tons – in production plant Hundreds of MT – in Synthesia your partner in Fine Chemicals

DyStar – Aliachem meeting 10 your partner in Fine Chemicals VUOS's technology / manufacture expertise include: Key know-how and technologies: Adamantanes N-heterocycles Halogen an sulfur derivatives Building Blocks Key chemistry Catalytic hydrogenation Phosgenation

DyStar – Aliachem meeting 11 your partner in Fine Chemicals VUOS's technology / manufacture expertise include: acetylation aldolisation amidation alkylation amination amoxidation alkali fusion arylhydrazines syntheses azocoupling benzoylation chiral synthesis chlorination chlorosulfonation cyclisation Claisen condensation decarboxylation dehydrohalogenation diazotisation elimination esterification Friedel-Crafts reaction heterocyclic synthesis hydrolysis reactions neutralisation nitration nitriles syntheses oxidation – catalytic/chemical oxidation in liquid phase rearrangement reduction with hydrazine and sodium borohydride sulfonation COOH

DyStar – Aliachem meeting 12 your partner in Fine Chemicals Kilolab Unit Phosgenation 2x reactors, 250 and 650 l 2x High performance rectification columns

DyStar – Aliachem meeting 13 your partner in Fine Chemicals Kilolab Unit Hydrogenation 3x autoclaves 100 l each, 60, 120 and 130 bar, up to 200˚C, Hastelloy C clad 1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad 1x autoclave 700 l, 100 bar, 200 o C, stainless steel 1x autoclave 1,000 l, 10 bar, 140˚C, stainless steel many autoclaves up to 10 l

DyStar – Aliachem meeting 14 your partner in Fine Chemicals Kilolab Unit Low temperature, RLi, RMgX, NaH 1 x glass reactor 50 l cooled down to – 80 ˚ C 1x glasslined reactor for NaH reactions (250 l) 3x glass reactors 100l for RLi, Grignard reactions

DyStar – Aliachem meeting 15 your partner in Fine Chemicals Kilolab Unit 20x glass reactors, 100 l each 6x glass lined reactors (200 – 1,500 l) 2x evaporators 50 l / h 4x stainless steel reactors (300 – 1,500 l) sufficient filtration and distillation capacity Multipurpose chemistry

DyStar – Aliachem meeting 16 your partner in Fine Chemicals Production Unit Production Plant Equipment 45x glass lined reactors, total vol. 70,000 l (500 – 5,000 l) 13x stainless steel reactors, total vol. 22,000 l (1,000 – 3,000 l) 8x High performance rectification columns sufficient filtration capacity (nutsches, centrifuges ) computer controlled

DyStar – Aliachem meeting 17 Toxicology, Ecology and Analytics your partner in Eco/toxicology and Analytics

DyStar – Aliachem meeting 18 Analytical Techniques: NMR Spectrometry Mass Spectrometry ICP IR Spectroscopy Chromatography UV-VIS your partner in Eco/toxicology and Analytics

DyStar – Aliachem meeting 19 Complete Offer of Services by VUOS-REACH CONSULTING TESTING REGISTRATION REACH your partner in Eco/toxicology and Analytics

DyStar – Aliachem meeting 20 Toxicology / ecotoxicology testing Sampling, analysing, evaluation of production waste streams (air pollution, effluents, solid wastes hazards) Environmental Impact Assessment Development/validation of new specialised analytical methods Toxicology, Ecology and Analytics your partner in Eco/toxicology and Analytics

DyStar – Aliachem meeting 21 Contacts General Manager: Dr. Karel Novák Phone: fax: Sales Manager: Miloš Jesenský,Ph.D. Phone: fax: R&D : Alois Koloničný, Ph.D. Phone: fax: Toxicology and Analytics: Viktor Mejstřík,Ph.D. Phone: fax: Process Engineering: Luboš Víšek Phone: fax: Our team is ready for co-operation with you