1. PARTNER FOR COOPERATION
VUOS Photo tour

2. Buildings 2
VUOS – PARTNER FOR COOPERATION

3. Buildings 215 employess Skilled – 25 % Secondary – 30%
University degree – 36%
Ph.D. degree – 9% 3
VUOS – PARTNER FOR COOPERATION

4. Laboratories Analytical methods NMR Spectrometry
Mass Spectrometry (LC/GC-MS)
ICP-AES
IR Spectrometry
Chromatography (HPLC, GC)
UV-VIS 4
VUOS – PARTNER FOR COOPERATION

5. Laboratories Toxicological tests Acute toxicity
In vivo and in vitro tests according to the OECD or EU methods:
Acute toxicity
Skin and Eye irritation
Sensibilisation
Repeated dose toxicity
Reproductive toxicity
Carcinogenicity
Mutagenicity 5
VUOS – PARTNER FOR COOPERATION

6. Kilolab – Multipurpose chemistry
20x glass reactors, 100 l each
6x glass lined reactors (200–1 500 l)
2x evaporators 50 l / h
4x stainless steel reactors (300–1 500 l) sufficient filtration and distillation capacity 6
VUOS – PARTNER FOR COOPERATION

7. Low temperature production line
1 x glass reactor 50 l cooled down to – 80 ˚C
1x glasslined reactor for NaH reactions (250 l)
3x glass reactors 100l for RLi, Grignard reactions 7
VUOS – PARTNER FOR COOPERATION

8. Low temperature production line
Reactors up to 630 l cooled down to – 80 ˚C
1x glass-lined reactor for NaH reactions (250 l)
3x glass reactors 100 l cooled down to – 40°C 8
VUOS – PARTNER FOR COOPERATION

9. Low temperature production line9
VUOS – PARTNER FOR COOPERATION

10. Phosgenation Reactors up to 1 600 l
2x High performance rectification columns
Laboratory phosgenation units from 1 to 30 l 10
VUOS – PARTNER FOR COOPERATION

11. Phosgenation 11
VUOS – PARTNER FOR COOPERATION

12. Hydrogenation
3x autoclaves 100 l each, 60, and 130 bar, up to ˚C, Hastelloy C clad
1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad
1x autoclave 700 l, 100 bar, ˚C, stainless steel
1x autoclave l, 10 bar, ˚C, stainless steel many autoclaves up to 10 l 12
VUOS – PARTNER FOR COOPERATION

13. Hydrogenation 13
VUOS – PARTNER FOR COOPERATION

14. Hydrogenation 14
VUOS – PARTNER FOR COOPERATION

15. Filtration Sufficient filtration capacity (nutsches, centrifuges) 15
VUOS – PARTNER FOR COOPERATION

16. Filtration 16
VUOS – PARTNER FOR COOPERATION

17. Centrifuge 17
VUOS – PARTNER FOR COOPERATION

18. Venulet 18
VUOS – PARTNER FOR COOPERATION

19. Reactors 52x glass lined reactors, total vol. 85 000 l (500 – 6 000 l)
16x stainless steel reactors, total vol l (1 000–6 000 l)
8x High performance rectification columns
sufficient filtration capacity (nutsches, centrifuges)
computer controlled 19
VUOS – PARTNER FOR COOPERATION

20. Reactors 20
VUOS – PARTNER FOR COOPERATION

21. Reactors 21
VUOS – PARTNER FOR COOPERATION

22. GMP Production Line certified since 2015
Production of API
Starting materials and advanced intermediates
Controlled finalization of final products
Glass-lined vessels 400 and 630 l
Stainless steel vessels 400 and 630 l
Filtration, Centrifuging and Drying
VUOS - PARTNER FOR COOPERATION

23. GMP Production Line certified since 2015
VUOS - PARTNER FOR COOPERATION

24. New Production Unit dedicated for production of Pharma Intermediates
Purpose
Dedicated for the production of pharma intermediates under GMP standard
5 reactors , total volume l, stainless steel and glass lined
Filtration, distillation, drying
Ready in the year 2018 24
VUOS – PARTNER FOR COOPERATION

25. New Unit dedicated for grinding, drying and blending of dry materials
Purpose
Dedicated for the for grinding, blending and drying of pharma intermediates under GMP standard
3 tray dryers in separate rooms with separate ventilation
Equipment for grinding and blending 25
VUOS – PARTNER FOR COOPERATION

26. Warehouse 26
VUOS – PARTNER FOR COOPERATION

27. Warehouse 27
VUOS – PARTNER FOR COOPERATION

28. Warehouse 28
VUOS – PARTNER FOR COOPERATION

29. www.vuos.com Výzkumný ústav organických syntéz a.s.
Rybitví č.p. 296, Rybitví, Czech Republic