1. FARMAK, a.s. CZECH REPUBLIC

2. INTRODUCTION FARMAK, a.s.
Czech, privately owned, independent middle-sized company with the tradition of industrial chemical production dates back to the year 1934.
Globally active
Flexible, reliable and customer oriented partner
Focused on R&D and manufacturing of:
niche API´s
advanced intermediates
Supportive in dossier development
Customer and employees oriented – The Essential is Inside
Farmak, a.s.

3. LOCATION FARMAK is easily accesible! Olomouc - Vienna = 190 km
Olomouc - Prague = 280 km
Olomouc - Brno = 80 km
Farmak, a.s.

4. HISTORY 1934 - start of industrial chemical production
establishment of state-owned company Farmakon (member of Spofa)
registration of joint-stock company FARMAK
Farmakon acquired by FARMAK (privatisation)
new R&D and QA/QC centre construction
installation of new cGMP kilolab
new Hall of Final Operations (HAFO) construction
new multipurpose production line installed
climatic chambers with water cooling system particle size distribution measurement on Malvern instrument
comprehensive Drying and Homogenization Technology Line
Farmak, a.s.

5. SALES AND MARKET More than 130 business partners across the world
Export level in sales around 90%
Farmak, a.s.

6. HUMAN RESOURCES
Approx. 250 employees
STRUCTURE
EDUCATION
Farmak, a.s.

7. QUALITY MANAGEMENT SYSTEM
Compliance with international cGMP standards: EU GMP Eudralex Volume 4, Part 2; ICH Q7; US FDA CFR’s and customer’s Quality Assurance Agreements
Inspected by authorities on regular basis
Czech State Institute for Drug Control
US Food and Drug Administration
Approved by
ISO & ISO International Standarts Certified Integrated System of QC and Environmental Protection
DMF & CEP Regulatory Documentation available
Farmak, a.s.

8. CHEMICAL EXPERTISE Chemistry of heterocyclic compounds
Grignard reactions
Various condensations
Friedel - Crafts reactions
Halogenations
Oxidations
Catalytic hydrogenations
Esterifications
Racemic mixture separations
Reductions (Zn, catalytic hydrogenations)
Farmak, a.s.

9. PRODUCTION FACILITIES
Facilities area: approx. 36,000 m2
2 GMP production halls (one is FDA approved)
Hall of Final Operations:
milling
micronizing
sieving
packaging
Supporting facilities:
warehousing
waste water treatment
water purification
Facility is ready to expand!
Farmak, a.s.

10. PRODUCTION HALLS
reactors Pfaudler
Glass-lined, stainless steel jacketed reactors (typical volume is 1,600 litres)
Total reactor capacity: 100 m3
Batch size kg
Reaction temperatures: between -20 and +300 °C
Reaction pressure: between -80 and +300 kPa
Product separation - centrifuges, filters, filter/driers (some of them of Hastelloy C22)
Drying equipment (some of them of Hastelloy C22
bag filters MAAP
Farmak, a.s.

11. KILOLAB Büchi ChemReactor CR: 2 x 60 L, 1 x 15 L
highest level of cGMP requirements
Büchi ChemReactor CR: 2 x 60 L, 1 x 15 L
Cryogenic technology (down to -90°C)
Glove box
Mobile pressure filter
HVAC system
Utility systems: non-water heating/cooling medium process nitrogen, process vacuum, hot water
Protected area for raw material dispensing 
0.2 – 5 kg batches
Farmak, a.s.

12. HALL OF FINAL OPERATIONS
Milling/micronization
Sieving
Custom packaging
HVAC system
Farmak, a.s.

13. R&D AND QA/QC CENTRE Analytical Centre – QC Department
production sample service – raw materials, intermediates, final samples
documentation – SOP’s, analytical instructions, CoA’s
standards, stability studies, validation of methods, water and air monitoring
R&D Analytical Department
structural analyses
purity analyses/impurity profile
development of analytical methods
Instrumentation
LCMS, GCMS, GC, HPLC/TLC
Capillary Electrophoresis
NMR, UV/VIS a IR Spectrometry, XRay
DSC
Laser Particle Size Analyses (Cilas+Malvern)
Farmak, a.s.

14. ECOLOGY AND SAFETY Environmental policy in line with FARMAK’s strategy
Involvement in the national System of Assistance in Accidents Related to Transportation of Dangerous Materials
Certified integrated system ISO9001 and ISO14001
Own waste water treatment plant
RESPONSIBLE CARE certificate holder for 20 years
Approved by SEDEX – Ethical and Responsible Supply Chain since 2015, site reference ZS
Farmak, a.s.

15. CONTACTS Feel free to contact us through our websites www.farmak.cz
Phone: ,
Fax: ,
Address: FARMAK, a. s.
Na vlčinci 16/3, Klášterní Hradisko
OLOMOUC, CZECH REPUBLIC
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