2 pt 3 pt 4 pt 5pt 1 pt 2 pt 3 pt 4 pt 5 pt 1 pt 2pt 3 pt 4pt 5 pt 1pt 2pt 3 pt 4 pt 5 pt 1 pt 2 pt 3 pt 4pt 5 pt 1pt DEFINITIONS NAME THAT ANTIGEN DISEASE ASSOCIATION KELL SYSTEM ENZYMES

This is the ability of an antigen to stimulate an antibody response.

Immunogenicity

This is the term for antigens that are present in less than 10% of the general population.

Low prevalence Low frequency Low incidence Familial Private

DAILY DOUBLE This is a known failure of an antigen-antibody reaction to yield a positive test result as a consequence of antibody excess.

Prozone

This is the term for a reaction in which one cell population is agglutinated, but a second cell population remains free.

Mixed-field

What term has been used to denote those antibodies which react weakly both when diluted or undiluted, but are present in high concentration.

HTLA (High Titer, Low Avidity)

After the ABO and Rh antigens, this antigen is the most immunogenic.

Kell

Name an antigen in the Kell system that is high prevalence.

k (Cellano) Kp b ( Rautenberg) Js b (Matthews)

This antigen is formed by a non-secretor who has inherited the genes lele.

Le c

Anti-Tj a is associated with this blood group system.

P

Name one antigen that is part of the C 4 molecule of complement, and therefore not an intrinsic part of the RBC membrane. (An example of an HTLA antibody)

Chido or Rodgers

This relatively uncommon antibody is found in up to 80% of patients with infectious mononucleosis.

Anti-i

This antigen, related to the Kell system, is associated with Chronic Granulomatous Disease.

Kx

The erythrocytes of individuals with this phenotype appear to resist invasion by Plasmodium vivax.

Fy (a-b-)

The Donath-Landsteiner antibody that is present in the serum of patients with paroxysmal cold hemoglobinuria (PCH) has this specificity.

Anti-P

A patient with a Mycoplasma pneumoniae infection will most likely develop a cold autoantibody with this specificity.

Anti-I

Antibodies of the Kell system generally react at this phase of testing.

AHG

Give two reasons a patient who had anti-K two years ago now appears to be compatible with two random donor units of red blood cells.

1.Both units are K negative. 2.The anti-K titer is too low to be detected.

Name three pairs of antithetical antigens at the Kell locus.

1.K and k (Kell and Cellano) 2.Kp a and Kp b (Penny and Rautenberg) 3.Js a and Js b (Sutter and Matthews)

Individuals of the Kell null phenotype may only be transfused with RBCs from other Kell null individuals because their plasma contains this antibody.

Anti-K u

A person with anti-K will be compatible with approximately this many random donors out of ten.

9

This enzyme is the most commonly used in routine Blood Banking.

Ficin

Papain is derived from this plant.

Papaya

Name 5 blood group antigens that are enhanced by enzymes.

Kidd, Lewis, Rh, Ii, P, ABO (Kidd Lewis has Ripples In his Pecs and Abs.)

DAILY DOUBLE Name 5 blood group antigens that are adversely affected by proteolytic substances.

MNS, Fy, Xg a (Many New Soldiers are destroyed in the Field by eXplosions.) Note: Sometimes Kell (Many New Soldiers are Killed in the Field by eXplosions)

These antigens of the Duffy system are enzyme resistant.

Fy3, Fy5 (and Fy4)