Effects of NGF. Developmental processes during which apoptosis can occur.

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Presentation transcript:

Effects of NGF

Developmental processes during which apoptosis can occur

Glial survival depends on growth factor from axon

Apoptosis vs. Necrosis

Apoptotic cell

DNA Fragmentation

Sources of trophic signals

Effects of targets and afferents

Signal-activation of caspase

Bax Activation PI3 Kinase NOT activated Akt NOT activated Cytosolic BAX migrates to mito. Cytochrome C release Caspase 9 Caspase 3

BDNF Trk B Y-P SHC RAS PI3 kinase Akt Blocks BAX migration To the mitochondria. No Cytochrome C release No Caspase activation Bax Inhibition