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Cell Division and Apoptosis III Chapter 17. Activation of a cyclin dependent kinase.

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Presentation on theme: "Cell Division and Apoptosis III Chapter 17. Activation of a cyclin dependent kinase."— Presentation transcript:

1 Cell Division and Apoptosis III Chapter 17

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3 Activation of a cyclin dependent kinase

4 CdK activity can be suppressed by inhibitory phosphorylation

5 CdK activity can be suppressed by inhibitory proteins

6 The Rb protein acts as a brake in mammalian cells

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9 Programmed Cell Death - Apoptosis

10 Digits in developing mouse paw are formed through apoptosis cells undergoing apoptosis

11 Apoptosis causes tadpole to lose tail

12 Necrosis vs. apoptosis

13 DVD clip 77

14 Caspase cascade occurs during apoptosis

15 Procaspase is activated by an active caspase

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17 4 types of intercellular signaling

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19 An animal cell depends on extracellular signals to survive or divide

20 An animal cell depends on extracellular signals to differentiate. Without extracellular signals the cell will die

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24 Platelet derived growth factor was the first mitogen isolated stimulates cell division during wound healing

25 Mitogens stimulate G1-Cdk and G1/S-Cdk activities

26 Ras is activated by tyrosine kinase

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28 p27 suppresses CdK activity

29 The Rb protein acts as a brake in mammalian cells

30 Excessive stimulation of mitogenic pathways leads to cell cycle arrest or apoptosis

31 Cell growth like cell division is also stimulated by extracellular signals

32 Comparison of nerve cell size vs. lymphocyte size

33 Fresh medium stimulates cell growth by adding mitogens

34 Many types of normal animal cells need anchorage to grow and proliferate

35 cell on small patchcell spread on large patch

36 Myostatin inhibits proliferation of skeletal muscle cells


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