Knight et al – Supplementary Table Supplemental Table 1: Cell line Densitometry AROSSIRT1 ARPE1965.810.7 WI380.131.9 MCF10A16.751.9 HCT116115.3177.6 HCT116.

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Knight et al – Supplementary Table Supplemental Table 1: Cell line Densitometry AROSSIRT1 ARPE WI MCF10A HCT HCT116 p53 -/ MCF R 2 value0.394

** Knight et al – Supplementary Figure 1 AROS 2 siRNA Mock Fold apoptosis induction SIRT1 siRNA AROS 1 siRNA AB n.s.

Knight et al – Supplementary Figure 2 mRNA expression (%) siRNA HCT116 mRNA expression (%) siRNA HCT116 p53 -/- mRNA expression (%) siRNA MCF7 mRNA expression (%) siRNA WI-38 mRNA expression (%) siRNA MCF10A Lamin AC mRNA SIRT1 mRNA AROS mRNA Lamin AC mRNA SIRT1 mRNA AROS mRNA Lamin AC mRNA SIRT1 mRNA AROS mRNA Lamin AC mRNA SIRT1 mRNA AROS mRNA Lamin AC mRNA SIRT1 mRNA AROS mRNA

Mock SIRT1 AROS siRNA Fold apoptosis vs. Mock *** Etoposide and TSA *** Mock AROS SIRT1 UV-C irradiation Knight et al – Supplementary Figure 3 Condition β-actin K382Ac Treatment p53 Etoposide and TSA UV-CControl * 37kDa 50kDa A B