Beta-Globin gene Activity From a kit by 3 D Molecular Designs3 D Molecular Designs Image from: Image from:

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Presentation transcript:

Beta-Globin gene Activity From a kit by 3 D Molecular Designs3 D Molecular Designs Image from: Image from:

Amino acid sequence aa Code amino acid mRNA codes DNA Codes M= ________ ________ ______ V= ________ ________ ______ MethionineAUGTAC valine GUU GUC GUA GUG CAA CAG CAT CAC

TEMPLATE strand = strand from which the RNA is actually transcribed. CODING (SENSE) strand = strand whose base sequence specifies the amino acid sequence. (IT MATCHES THE mRNA MESSAGE EXCEPT IT HAS T’s instead of U’s)

Sickle Cell disease (anemia)

5 kinds of hemoglobin subunits Alpha (σ) Beta (β) Gamma (ϒ) Delta (δ) Epsilon (ϵ)

Adult hemoglobin σ 2 β 2 - 2% of adult hemoglobin = σ 2 δ 2 Embryonic hemoglobin σ 2 ϵ 2 Fetal Hemoglobin σ 2 ϒ 2 Greater affinity for oxygen than adult hemoglobin last seven months of development in uterus in the newborn until roughly 6 months old Sickle cell hemoglobin σ 2 β 2 Mutation in β chain