Institute for Resource Efficient and Sustainable Systems Graz University of Technology Zero Emissions Case Study May 13, 2005 Poster Presentation Zero Emissions - Case Study Pharmaceutical Company at „Integrative Approaches Towards Sustainability“ Jurmala, May 11-14, 2005, Latvia Christian Zwatz Institute for Resource Efficient and Sustainable Systems Graz University of Technology

Institute for Resource Efficient and Sustainable Systems Graz University of Technology Zero Emissions Case Study May 13, 2005 Action Plan for Case Studies A Local Water Supply B Soften Water C Steam Boiler D Ion Exchanger E Heating for distillation holding tank F Distillation Device G Distillation holding tank H Water Cooler I Base of product J Cleaning of the batching tank K Cooling of the product L Filling M Autoclave N End product O Canalisation P Re-cooling / Air Condition X Mixture of water for cooling water recirculation Z Cooling Pond A Local Water Supply B Soften Water C Steam Boiler D Ion Exchanger E Heating for distillation holding tank F Distillation Device G Distillation holding tank H Water Cooler I Base of product J Cleaning of the batching tank K Cooling of the product L Filling M Autoclave N End product O Canalisation P Re-cooling / Air Condition X Mixture of water for cooling water recirculation Z Cooling Pond Creating process flow charts Mass and heat balances and analysis of critical points Searching for relevant parameters Sankey chart Prevention and/or recycling of emissions and waste Zero Emissions Matrix and decision tree ZEW methods Closed loop engineering Heat integration and by - products Process optimisation List of measures Implementation of Zero Emissions Techniques

Institute for Resource Efficient and Sustainable Systems Graz University of Technology Zero Emissions Case Study May 13, 2005 Flow Chart and Critical Point critical point C Steam Boiler D Ion Exchanger F Distillation Device I Base of product K Cooling of the product L Filling M Autoclave 1 Tape water 2 Demineralised water 3 Steam Recirculation 4 Steam 5 Distilled water 6 Product 7 End product 8 Effluent Max. cooling time 25 min Outlet Temperature 60°C Permissible Inlet Temperature: 45°C Max. cooling water inlet temperature for Autoclave (M), basis for closing loops Minimize Energy Consumption Potential for optimisation

Institute for Resource Efficient and Sustainable Systems Graz University of Technology Zero Emissions Case Study May 13, 2005 List of Measures Max. cooling water inlet temperature - Figure 5 for Autoclave (M), basis for the internal closed loop Internal closed loop – Figure 3 and 4: Cooling of the autoclave M with process water from G and H Waste water of the cleaning process in J can be used as boiler feed water in C Using of the complete demineralised water from D for cooling the distillation device F Use of the industrial heat in the surrounding area External closed loop External Loop Cooling Pond Inflow : V= m³/a T in = 40 – 60°C Outflow: V= m³/a Tout = 30°C A pond = 300 m²

Institute for Resource Efficient and Sustainable Systems Graz University of Technology Zero Emissions Case Study May 13, 2005 List of Measures Internal closed loop Secondary use of cooling water from the process for cooling autoclave Water of the cleaning process can be used as boiler feed Optimisation of the distillation device: Using cooling water for feed

Institute for Resource Efficient and Sustainable Systems Graz University of Technology Zero Emissions Case Study May 13, 2005 Poster Presentation Zero Emissions - Case Study Pharmaceutical Company at „Integrative Approaches Towards Sustainability“ Jurmala, May 11-14, 2005, Latvia Christian Zwatz Institute for Resource Efficient and Sustainable Systems Graz University of Technology