طريقة عمل العقاقير Mode of drug action

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Presentation transcript:

طريقة عمل العقاقير Mode of drug action الدفاعات العصابية : دفاع ضد الاكتئاب Neuroses (against psychic pain) الفصام : التهديد الأساسى الاكتئاب دفاع ضد البارانويا Depression :against Paranoia البارانويا: دفاع ضد الفصام Paranoid :against Paranoia Schizophrenia

الإبداع : تناغم كل المستويات وتبادلها Creative Health Synthesis العادية (وفرط العادية )= الاغتراب اليومى : دفاع ضد كل من المرض والإبداع معا Normal Defenses Alienation الإبداع : تناغم كل المستويات وتبادلها Creative Health Synthesis الدفاعات العصابية : دفاع ضد الاكتئاب Neuroses (against psychic pain) الفصام : التهديد الأساسى الاكتئاب دفاع ضد البارانويا Depression :against Paranoia البارانويا: دفاع ضد الفصام Paranoid :against Paranoia Schizophrenia

الدفاعات العادية وتسمى الصحة الموقف الاكتئابى حيرة العلاقة بالأخر ثنائية الوجدان ambivalence Normal Defenses + Health الدفاعات العادية وتسمى الصحة (لا مانع !!!!) Neurotic (Ps.normal) + stability Depressive position الموقف البارنوى الكر والـفر Fight flight Paranoid Position Schizoid Position الموقف الشيزيدى اللاموضوع – فى الرحم No object مراحل النمو Stages of development

(العادية المغتربة غالبا) الاكتئاب الألم النفسى : دفاعات أقل Neurosis (normal + alienation). الغطاء العصابى (العادية المغتربة غالبا) Depression Psychic pain : less defensive الاكتئاب الألم النفسى : دفاعات أقل Paranoid state & symptoms حالات وأعراض بارانوية Schizophrenia الفصام مراحل تارجع (فشل) الدفاعات بالتتالى لتعرية مستوى يعلن المرض تلوالمرض Stages of subsequent failure of defenses uncovering latent organizations to declare a disorder after another

المفهوم الأحدث/الأقدم لتعدد الذوات تعدد الذوات بمعـنى : أن التعدد مطلق بحيث يصبح لكل وحدة سلوكية فى الظاهر والباطن وعيها الخاص

التدهور = المر ض الانقراض التطور = النمو الإبداع مفتوح النهايية (متضمنا إيمانا موضوعيا) التدهور = المر ض الانقراض التدهور – الاغتراب – المرض النفسى الناس مستخبية فى هدومها!!

Stabizers e.g.Carbamazepine Tryptizol Anxiety Depression Minor Tranquil. This is absolutely not the case The actual art is the result of training. Anxiety Floating Prothiaden Anxiety Panic Stabizers e.g.Carbamazepine Tryptizol Anxiety Depression Thioridazine Mellar. Depression (1) Chlorpomazine Depression (2) Perphenazine Trilaf. Schizo-agitatied Trifluperazine Stelaz Schizo-depressive Clozaril Broad Spectrum Randolectil Schiz. Paranoid ++ Haloperidol Schiz. Paranoid +++ Majeptil + Schiz. Chron. Undif Haloperidol Schiz. Disorg. + Mania. Almost none !!! Schiz. Simple

9 Changing the whole pattern Hypothetical Brain Organization Not necessarily normal Pathological excess of Some transmitter Specific drug abolishing the excess الفكرة أنه بزيادة أو نقص مادة معينة بالمرض أو بالعلاج يتغير التنظيم الكلى للدماغ وهذا يظهر إكلنيكيا فى كلية نوع التغير فى العلاقة بالموضوع , والعمل, و نبض الوجدان

3 Changing the whole pattern Hypothetical Brain Organization Not necessarily normal Pathological excess of Some transmitter Specific drug abolishing the excess الفكرة أنه بزيادة أو نقص مادة معينة بالمرض أو بالعلاج يتغير التنظيم الكلى للدماغ وهذا يظهر إكلنيكيا فى كلية نوع التغير فى العلاقة بالموضوع , والعمل, و نبض الوجدان

Pathological excess of Some transmitter Specific drug abolishing the excess 6 Changing the whole pattern Hypothetical Brain Organization Not necessarily normal الفكرة أنه بزيادة أو نقص مادة معينة بالمرض أو بالعلاج يتغير التنظيم الكلى للدماغ وهذا يظهر إكلنيكيا فى كلية نوع التغير فى العلاقة بالموضوع , والعمل, و نبض الوجدان

Brain is a complex processor of ENERGY and INFORMATION Haloperidol Depression Schizo depressive Relatively Recent Organization of Information (Recent Brain) Akasthesia- Dystonia Information (More Recent Brain) More Recent Organization of Energy Entangled in the muscles via basal G. Mobilization of Energy Haloperidol Schiz. Disorg. Occasionally mobilization is to oldest mental state=> Catatonia

Haloperidol a potent narrow spectrum neuroloptic, mainly acting on D1 and….. Clozaril No inhibition of apomorphine or amphetamine induced stereotypic behavior No induction of catalepsy No dopinetgic or GABAergic over sensitivity No depolarization block of nigostriatal dopimine n. Relatively higher 5-Ht2 to D2 blocking ration less D2 but greater D1 and D 4 receptor blockade ALL SUCH DATA ARE NOT SURE THE MODE OF ACTION. THE MAIN POSSIBLE REPONSIBLE FACT IS This drug has a wider range of action on some billions of neurons on multiple levels simultaneously

Brain is a complex processor of ENERGY and INFORMATION Depression By- passes Schizo depressive Towards Object (if any) No Akasthesia- Dystonia Depression, if there is an object , it is object relational Energy is mobilized beyond the basal G. Mobilization of Energy Clozaril Acts on Multiple sites (transmitters D2,D4, Serotnin …etc. Schiz. Disorg.

Brain is a complex processor of ENERGY and INFORMATION The more relating to real object the more energy is flowing properly and re-harmonizing is possible. E.g. in intensive Individual Therapy The less neuroleptics are needed Object relational Depression Mobilization of Energy Towards real object Haloperidol Schiz. Disorg. Diminish the dose

Brain is a complex processor of ENERGY and INFORMATION Mobilization of Energy The center refers symbolically to the “hot seat” Potent Neuroleptic + (in) Group Therapy The more real relations are established the less neuroleptics are needed Towards real persons in the group