1 P ROMOTING THE CREATION, RELOCATION AND DEVELOPMENT OF BIOTECH COMPANIES

2 Genopole®: From a Bio-Park to a Bio-Cluster... Companies Hospital University Research A continuum dedicated to Biotechnology

3 Genopole® : a Biopark fully integrated in the Medicen Paris Region Bio-cluster  Non-Profitable Organisation Incorporated in 1998 Incorporated in 1998 Creation & Development of a Bio-Park : Companies & Research Labs Creation & Development of a Bio-Park : Companies & Research Labs 30 Km

4 Genopole®: Building the most favorable environment to develop Biotech companies… InternationalNetwork Shared Technical platforms Incubation and developmentPrograms Versatile Real Estate Offers and Services ClinicalNetwork InternationalScientificenvironment Biotech Companies Pre seed Fund

5  20 research labs, incl. 3 national-scale centres More than 900 scientists More than 900 scientists From major National Research Agencies From major National Research Agencies o … Genopole®: A stimulating Collaborative Scientific & Education Environment Research  Evry University and 3 engineer schools more than 12,000 students (34 % in wet sciences and engineering) and 400 professors more than 12,000 students (34 % in wet sciences and engineering) and 400 professors  Ambitious Integrative Programs iStem : Institute for Stem Cells (2005) iStem : Institute for Stem Cells (2005) iSSB : Institute for Systems and Synthetic Biology (2009) iSSB : Institute for Systems and Synthetic Biology (2009) Institute for Biomaterials (2010) Institute for Biomaterials (2010)

 A new hospital is build on Genopole® campus Genopole®: a new hospital and a center for clinical and translational research Latest & Largest General Hospital build in France Latest & Largest General Hospital build in France 1,000 beds 1,000 beds Opening May 2011 Opening May 2011  Genopole coordinates the construction of a center for clinical and translational research Clinical 3,000 m² 3,000 m² New Approaches New Approaches Opening late 2011 Opening late 2011

7 Our facilities include space from “plug ‘n play” offices for entrepreneurs to customised tenant lab & office spaces for 50 to 300 m² wet lab & office suites for 50 to 300 m² wet lab & office suites Fully equipped with benches, sinks, deionised water, autoclave, freezers, rt-PCR, … Fully equipped with benches, sinks, deionised water, autoclave, freezers, rt-PCR, … Genopole®: more than m² dedicated to the development of life science companies  Incubator with shared laboratory equipment Offices fully furnished, Meeting rooms,... Offices fully furnished, Meeting rooms,... Real Estate  Business Center (20-50 m²):  customized spaces / specific demand and lay out for 300 to m² and more wet lab, L2 & office suites for 300 to m² and more wet lab, L2 & office suites

Genopole®: State of the art shared technical platforms and equipment Infrastructures 8 15 Platforms/Equipments end Platforms/Equipments end 2009 Management : 13 public labs, 1 private and 1 Genopole Management : 13 public labs, 1 private and 1 Genopole Genopole investments ~ 20 M€ Genopole investments ~ 20 M€ Headcount : 68 persons Headcount : 68 persons Cumulated surface ~ 4200 m 2 Cumulated surface ~ 4200 m 2 5 obtained national quality label 5 obtained national quality label 2 ISO 9001 v 2000 certification & 2 planned in ISO 9001 v 2000 certification & 2 planned in more than 300 scientific publications more than 300 scientific publications 8 patents/licences 8 patents/licences  Sharing expertise, skills and resources

Genopole®: State of the art shared technical platforms and equipment Infrastructures 9  CERFE and CERFAP(Animal facilities)  Cell and Small Animal Irradiator  Imaging and cytometry platform  Bioinformatic annotation  DNA chips production  Mass spectrometry platform  (augmented reality and virtual environment)  Plant DNA Microarray platform  Biophotonics Platform  Structural Biology Platform (NMR, AFM)  Transmission electron microscopy  DNA and cells Bank  HTS Platform  Cell sorting station  Incubator shared equipements 15 Platforms

Genopole®: GMP production centers for drugs of the future Infrastructures The Present & the Future A GMP compliant biomanufacturing center for proteins from mammalian cells (biotherapy, monoclonal antibodies) A GMP compliant biomanufacturing center for proteins from mammalian cells (biotherapy, monoclonal antibodies) A GMP compliant viral vector bioproduction center (Genethon) A GMP compliant viral vector bioproduction center (Genethon) A production centre of enzymes and biocatalysis for industrial use. A production centre of enzymes and biocatalysis for industrial use. A GMP biomanufacturing centre using alternative techniques : bacteria, yeast, plants… A GMP biomanufacturing centre using alternative techniques : bacteria, yeast, plants… An GMP oligonucleotides production center in partnership An GMP oligonucleotides production center in partnership A Laboratory to develop and optimise the best expression systems A Laboratory to develop and optimise the best expression systems A centre for filling, packaging and delivering products under GMP compliant A centre for filling, packaging and delivering products under GMP compliant

Genopole®: a team dedicated to foster creation and development of biotech companies Incubation Finance Science(s) IP Team Clinic&Reg Scale up Finance Science(s) Market Compet Bus Dev IP Team Clinic&Reg Scale up Market Compet. Bus Dev  A Team of 6 multidisciplinary Project Managers Combining solid complementary backgrounds in pre-incubation, IP, finance, valuations, biz. dev., fund raising, licensing, … Combining solid complementary backgrounds in pre-incubation, IP, finance, valuations, biz. dev., fund raising, licensing, …

Genopole®: a team dedicated to foster creation and development of biotech companies… Incubation Legal support for corporate development Legal support for corporate development  Incorporation Phase  Development Phase Raise Private Money Raise Private Money Network of BAs and VCs Network of BAs and VCs Raise Private Money Raise Private Money Network of BAs and VCs Network of BAs and VCs Business Development Business Development Direct Access to all French Tech Transfer Offices (CNRS, Inserm, CEA, AP-HP, …) Direct Access to all French Tech Transfer Offices (CNRS, Inserm, CEA, AP-HP, …) Network of business opportunities Network of business opportunities Network of international experts Network of international experts Business Development Business Development Direct Access to all French Tech Transfer Offices (CNRS, Inserm, CEA, AP-HP, …) Direct Access to all French Tech Transfer Offices (CNRS, Inserm, CEA, AP-HP, …) Network of business opportunities Network of business opportunities Network of international experts Network of international experts Raise Public Money Raise Public Money Direct relations with OSEO, CFI, ANR, Medicen, … Direct relations with OSEO, CFI, ANR, Medicen, … Raise Public Money Raise Public Money Direct relations with OSEO, CFI, ANR, Medicen, … Direct relations with OSEO, CFI, ANR, Medicen, … Access to the Best R&D tax Credit in Europe Access to the Best R&D tax Credit in Europe Cover 50% of all R&D costs in the 1 st year Cover 50% of all R&D costs in the 1 st year 40% the 2 nd year and 30% in subsequent years up to €100 million and 5% above 40% the 2 nd year and 30% in subsequent years up to €100 million and 5% above Access to the Best R&D tax Credit in Europe Access to the Best R&D tax Credit in Europe Cover 50% of all R&D costs in the 1 st year Cover 50% of all R&D costs in the 1 st year 40% the 2 nd year and 30% in subsequent years up to €100 million and 5% above 40% the 2 nd year and 30% in subsequent years up to €100 million and 5% above - Tailor-made Incubation Programs - Drug Development Drug Development Network of preclinical & clinical experts Network of preclinical & clinical experts Access to French and European authorities: AFSSAPS or EMEA Access to French and European authorities: AFSSAPS or EMEA Drug Development Drug Development Network of preclinical & clinical experts Network of preclinical & clinical experts Access to French and European authorities: AFSSAPS or EMEA Access to French and European authorities: AFSSAPS or EMEA

 Genopole provides a whole list of services dedicated to young biotech companies Genopole®: a list of services to foster the development of Biotech companies Senior administrative officers, Accounting, quality assurance, onsite IT network support, human resources management, … Senior administrative officers, Accounting, quality assurance, onsite IT network support, human resources management, …  Genopole coordinates an European Grant Service dedicated to SMEs... Brings support to preparation and application phases but also in the management of funded project Brings support to preparation and application phases but also in the management of funded project Bureau Europe Genopole® Incubation  Genopole organises access to : Electronic libraries including scientific and competitive databases Electronic libraries including scientific and competitive databases Annual Calls for Equipments and Post-Docs Annual Calls for Equipments and Post-Docs

 G1J - Genopole pre-seed Life Sciences Capital Fund Genopole®: with G1J IdF access to a pre-seed Fund Initial Capital: 2.1 M€ - 16 private investors Initial Capital: 2.1 M€ - 16 private investors Investment/project: – € Investment/project: – € « From 1st day to 1st round of financing » Allows access to the Oseo grant system and to National, Regional & EU grants Equity raise: 6 M€ Equity raise: 6 M€ brings G1J to the Proof of Concept Fund level brings G1J to the Proof of Concept Fund level Investment/project: – € Investment/project: – € Incubation  G1J - Genopole Regional Life Sciences Capital Fund

15 Genopole®: More than 80 currently incorporated companies and active projects … LTK Pharma NanoBH GlobalBio Energy Texcell GENOPOLE ® ENTREPRISES in biotech companies 1023 FTE M€ fund raised M€ sales / 30 companies 670 granted/penting patents 28 products from IND to Phase III & market

 Genopole manages an international network Genopole®: an international network oriented to biotech companies with international Cies, pharma laboratories, foreign bioincubators and international venture capital institutions, with international Cies, pharma laboratories, foreign bioincubators and international venture capital institutions,  Genopole is member of several European consortium with European bioparks International BioLink (FP5) Oxford, Munich, Cagliari, Jerusalem, Cardiff BioLink (FP5) Oxford, Munich, Cagliari, Jerusalem, Cardiff Natibs (FP6) Berlin, Barcelona, Karolinska, Tallinn, Tel Aviv, Inno Natibs (FP6) Berlin, Barcelona, Karolinska, Tallinn, Tel Aviv, Inno CEBR (FP6) Cambridge, Oxford, Berlin, Munich, Heidelberg, Barcelona, Uppsala, Tallinn, Lyon CEBR (FP6) Cambridge, Oxford, Berlin, Munich, Heidelberg, Barcelona, Uppsala, Tallinn, Lyon Bio-CT (FP7) Torino, Cambridge (CEBR), Barcelona, Berlin, Debrecen & Inno Bio-CT (FP7) Torino, Cambridge (CEBR), Barcelona, Berlin, Debrecen & Inno

Genopole® Campus 1 Today & tomorrow Pépinière CCIE Genopole Entreprises Centre de Bioproduction Projet Gamma : production GM P de lots cliniques de vecteurs viraux de Généthon 2011 Centre Hospitalier Sud-Francilien 2011 Projet Crèche 2011 Restaurant inter-entreprises et Résidence hôtelière 2011 Genavenir : Pôle d’entreprises et de laboratoires Genavenir : Hôtels d’entreprises Centre de Recherche Clinique et Translationnelle

18 18  20 research labs jobs -  70 biotech companies – jobs-  A comprehensive m² real estate offer  A team dedicated to development  Services and a Europe Grant service  17 platforms and equipments  Corbeil Evry Hospital & Clinical and Translational Research Center  GMP Biomanufacturing Center opening soon and 4 others biomanufacturing project running Our achievements...

For more Informations … 19 Emmanuel DIAZ Economic Development Director Place de l’Agora BP EVRY Cedex Tel + 33 (0) Caroline Mercier Head of networks and investments Essonne Development Agency 6 cours Monseigneur Roméro Evry Cedex Fixe : + 33 (0) mail : Delphine Beau Life Sciences Director Paris Region Economic Development Agency Tel :(+33 (0) Mob.:+33 (0) Eric Lameignère Genopole Entreprises Director 5, rue Henri Desbruères F Evry Cedex Tel.: +33 (0) Tel :(+33 (0) Mob.:+33 (0)