Conducting NIH-Sponsored Social and Behavioral Science for the Past 15 Years: Reflections from South Africa Heidi van Rooyen Executive Director: HSRC Professor:

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Presentation transcript:

Conducting NIH-Sponsored Social and Behavioral Science for the Past 15 Years: Reflections from South Africa Heidi van Rooyen Executive Director: HSRC Professor: University of the Witwatersrand @HSRCza Share your thoughts on this presentation with #IAS2019

No conflicts of interest DISCLAIMER… No conflicts of interest

Vulindlela, uMgungundlovu District, KwaZulu-Natal Population: 1 126 585 (2016) Density: 117.3 (perkm2) HIV Testing Coverage: 24.70% (2017/18) HIV Prevalence: 29.70% (2017) ART Retention: 64.00% (2017) Unemployment: 30.40% (2016) Youth Unemployment: 39.50% (2016)

NIMH/HPTN 043 Project ACCEPT 2003 - 2011 Project cooperative grant mechanism Total budget: $24,292,793 3 US institutions UCLA UCSF Johns Hopkins 5 African and Asian Institutions Chiang Mai, Thailand Kisarawe, Tanzania Mutoko, Zimbabwe Soweto, South Africa Vulindlela, South Africa

NIMH Project ACCEPT / HPTN 043 UO1 Timeline of NIH Awards 12 NIH awards through collaborative engagement Wide range of grant awards: Duration: 2-8 years Budgets: U01: ZAR 58M R01: ZAR 26M – ZAR 11M RC4: ZAR 3M – ZAR 4M R21: ZAR 1.5M – ZAR 2.7M Scope: Formative work Interventions Feasibility studies RCTs and longitudinal cohorts Deliver Health R21 Deliver Health R21 Zwakala Ndoda R01 Zwakala Ndoda R01 Lotto to Link R21 Lotto to Link R21 Biolink R21 Biolink R21 Family Based RCT R21 Family Based CT R21 Linkages & Samba RC4 Linkages & SAMBA RC4 Combination Prevention RC4 Combination Prevention RC4 Couples in Context R01 Couples in Context R01 Multiple Prev. Packages Pilot R01 Multiple Prev. Packages Pilot R01 Project SIZE R01 Project SIZE R01 Masihambisani R01 Masihambisani R01 NIMH Project ACCEPT / HPTN 043 U01 NIMH Project ACCEPT / HPTN 043 UO1 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022

Opportunities Lifecourse Address the behavioural and social determinants of HIV: Children and youth Couples Men and women Through various NIH mechanisms: Formative exploratory work Intervention development RCTs Implementation science and evaluations Longer studies provide a platform to leverage other work, test out new ideas FAMILIES COMMUNITIES SOCIETY Lifecourse Pregnancy Postnatal Early childhood Middle childhood Adolescence Adulthood

Sustainability

Benefits of collaborative science

Lessons Learnt Competitive and rigorous process Requires systematic, succinct distillation of the science and regulatory considerations Latitude post award to engage with programme officers Refine the science, adapt original proposal Opportunity to develop human capital, resources and processes beyond individual projects Allows for innovative, participatory and engaged science Innovative methodologies Mobile data collection Point of Care devices Biometric participant registration