Expression of 20 genes significantly associated with reduced survivability in GBM is shown across 33 TCGA diseases. Expression of 20 genes significantly.

Slides:



Advertisements
Similar presentations
Proteins enriched in HCs are strongly associated with genetic hearing/balance impairment. Proteins enriched in HCs are strongly associated with genetic.
Advertisements

Volume 44, Issue 1, Pages (January 2016)
Fig. 8. Recurrent copy number amplification of BRD4 gene was observed across common cancers. Recurrent copy number amplification of BRD4 gene was observed.
Hnf4g importance in human colon cancer organoids and regulation of the Hnf4a locus Hnf4g importance in human colon cancer organoids and regulation of the.
High retinoblastoma (RB) expression is prevalent in human pancreatic ductal adenocarcinoma (PDA) and is of prognostic relevance in independent cohorts.
The immune metagene model has prognostic value in IBE but not in IBD breast cancer. The immune metagene model has prognostic value in IBE but not in IBD.
A systems medicine approach for personalized chronotherapeutics.
European Urology Oncology
Figure 1 Hierarchical clustering (HCL) outcome of all tested samples with the expression profile of the case report set as unknown Hierarchical clustering.
Heatmap displaying consistent similarity-based OTU results based on SIMPER intragroup similarity analyses for the tissue, mucus, holobiont, and seawater.
Consensus of Melanoma Gene Expression Subtypes Converges on Biological Entities  Martin Lauss, Jeremie Nsengimana, Johan Staaf, Julia Newton-Bishop, Göran.
Volume 7, Issue 4, Pages (April 2005)
Volume 5, Issue 4, Pages e5 (October 2017)
(A) Hierarchical clustering was performed to identify groups of patients with similar RNASeq expression of 20 genes associated with reduced survivability.
Volume 25, Issue 6, Pages e4 (November 2018)
Integrated protein co‐expression and differential expression across the ALS‐FTD disease continuum Integrated protein co‐expression and differential expression.
Genome-wide expression screen identifies novel hypoxia-regulated genes
Volume 4, Issue 3, Pages (August 2013)
Patterns of Somatically Acquired Amplifications and Deletions in Apparently Normal Tissues of Ovarian Cancer Patients  Leila Aghili, Jasmine Foo, James.
Figure 2 Correlation between total IgG levels and anti-AQP4 IgG titer
Volume 22, Issue 3, Pages (January 2018)
Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2  Lukas M. Simon, Edward S. Chen, Leonard C. Edelstein,
Figure 2 LocusZoom plots
Volume 24, Issue 12, Pages e5 (September 2018)
Volume 88, Issue 4, Pages (November 2015)
Volume 22, Issue 3, Pages (January 2018)
Figure 1. Nanopore methylation calls are consistent with expected results and established technologies. (A) Metaplot of ... Figure 1. Nanopore methylation.
Functional enrichment of differentially expressed genes.
Common experimental groups and drug-effect profiles in assays of pain-related CPA. (A–D) Common conditioning regimens in each of the two compartments of.
Volume 64, Issue 6, Pages (December 2016)
Figure 2 Functionally significant genes
Volume 4, Issue 3, Pages e3 (March 2017)
Varying Intolerance of Gene Pathways to Mutational Classes Explain Genetic Convergence across Neuropsychiatric Disorders  Shahar Shohat, Eyal Ben-David,
Figure 1. Profiles of the top 50 mRNA probes of the first gene signature identified in the South African cohort. ... Figure 1. Profiles of the top 50 mRNA.
David Quigley  Journal of Investigative Dermatology 
Volume 7, Issue 2, Pages (August 2010)
Toray microarray analysis of the four groups of patients (A) and in patients with calcium score >100 (B). Toray microarray analysis of the four groups.
Trends in metabolite predictability in terms of key gene contributors.
Canonical gliomagenesis mediators EGFR, P53, and retinoblastoma protein (RB1) are important for cancer signaling. Canonical gliomagenesis mediators EGFR,
Three drug delivery strategies for crossing the blood-brain barrier.
Figure 4. The N:M ratio is significantly increased in patients with ALS and correlates with disease progression The N:M ratio is significantly increased.
Matrix risk model showing the probability of SRP in patients with moderate disease activity after 3 years of MTX treatment. Matrix risk model showing the.
Figure 1 bvFTD PINBPA network
Analysis of renal transcriptome responses identifies LX-regulated transcriptional networks. Analysis of renal transcriptome responses identifies LX-regulated.
Reanalysis of an existing experiment using ADAGE
Figure 1. Identification of three tumour molecular subtypes in CIT and TCGA cohorts. We used CIT multi-omics data ( Figure 1. Identification of.
Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci  Eilis Hannon, Mike Weedon, Nicholas Bray,
Differences in Verrucomicrobia genera across plant community types.
MK-8628 modulates transcriptional signatures of activated T lymphocytes. MK-8628 modulates transcriptional signatures of activated T lymphocytes. Gene.
Expression profiles of 87 miRNAs expressed in SC
Fig. 2 Inflammatory pathways with STAT1 as a key regulator are enriched in ICB responsive tumors in mouse models and patients. Inflammatory pathways with.
Distinct molecular and clinical correlates of H3F3A mutation subgroups
Fig. 2 Expressions of cll, abd-A, and Abd-B by qRT-PCR.
Expression analysis of IGFBP-3 using human whole-genome microarray.
Fig. 4 Identification of C
PD-L1 expression correlates with T-cell markers and an IFN response signature in human melanomas. PD-L1 expression correlates with T-cell markers and an.
Fig. 1 The seven nasal CSTs and their respective bacterial densities shown in boxplots and composition shown in heatmap visualization and non-metric multidimensional.
Fig. 4 Differential histone modifications at promoters in various brain cell populations. Differential histone modifications at promoters in various brain.
Progression-free (a) and overall (b) survival by age subgroup, Kaplan-Meier plots. Progression-free (a) and overall (b) survival by age subgroup, Kaplan-Meier.
Bortezomib induces an NRF2 signature and NRF2 protein in tumor cells from leukemic MCL. Gene sets regulated by bortezomib (Supplementary Tables S3 and.
Coexpression of other immune genes with ImSig core signatures.
Influence of ASGR2 expression on survival.
Frequently mutated genes in colorectal cancer.
Host gene expression changes following exposure to the microbiota.
Gene expression heatmap of non–T-cell-inflamed, intermediate, and T-cell–inflamed testicular germ cell tumors from TCGA. Genes are on the row, and samples.
Integrated analysis of gene expression and copy number alterations.
Highly metastatic PDAC cells have a unique gene signature, which is not preserved in metastases but predicts poor patient outcome. Highly metastatic PDAC.
Fig. 4 Matrix for intersections of differentially expressed transcripts between RNAiAFL transgenic and null kernels. Matrix for intersections of differentially.
Composition and Function of Mutant Swi/Snf Complexes
Kaplan-Meier (K-M) curves of progression-free survival (PFS) in 54 patients with metastatic gastric cancer treated with RAD001. Kaplan-Meier (K-M) curves.
Presentation transcript:

Expression of 20 genes significantly associated with reduced survivability in GBM is shown across 33 TCGA diseases. Expression of 20 genes significantly associated with reduced survivability in GBM is shown across 33 TCGA diseases. Gene expression from each patient sample was converted to a z-score, and z-scores were recalculated across all diseases for each gene to show relative expression. Regions of the heatmap are circled to highlight genes with consistent higher expression (10th percentile >0.5) and previously published support for relevance to disease progression (cyan) or high expression without previously published support for disease progression (purple). Diseases are ranked by decreasing average expression and ribbon on the right is colored to indicate average expression per patient sample. Andrea Shergalis et al. Pharmacol Rev 2018;70:412-445 Copyright © 2018 by The Author(s)‏