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Figure 2 Functionally significant genes

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Presentation on theme: "Figure 2 Functionally significant genes"— Presentation transcript:

1 Figure 2 Functionally significant genes
Functionally significant genes (A) 3D chromatin interaction (Hi-C) and eQTL analysis. Hi-C revealed significant interaction between GWAS variants in LPPR1 and 17 other genes on chromosome 9 (FDR < 1E-6, shown in orange). An SNP in LPPR1 was associated with the expression of GRIN3A (FDR = 4E-4, shown in green). (B) Tissue-specific expression of LPPR1, GRIN3A, and genes in Hi-C with LPPR1. Colors reflect average expression (log2 transformed) from highest (red) to lowest/absent (blue). (C) Age-specific expression of the genes in the brain. LPPR1 expression decreases with age. Zachary D. Wallen et al. Neurol Genet 2018;4:e271 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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