Ectopic expression of caveolin-1 in ZR75 human breast cancer cells downregulated survivin and decreased cell proliferation. Ectopic expression of caveolin-1.

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Ectopic expression of caveolin-1 in ZR75 human breast cancer cells downregulated survivin and decreased cell proliferation. Ectopic expression of caveolin-1 in ZR75 human breast cancer cells downregulated survivin and decreased cell proliferation. ZR75 cells were stably transfected with the plasmids pLacIOP (-) or pLacIOP-caveolin-1 (+). (A) Survivin and caveolin-1 expression was assessed by western blotting. A representative result is shown. Residual survivin protein levels were 0.53±0.09 as determined in three independent experiments (*P<0.05). (B) Survivin mRNA content was analyzed by RT-PCR. Residual survivin mRNA levels were 0.50±0.06 as averaged from three independent experiments (*P<0.05). (C) Cell proliferation was measured by the MTS® assay in the presence and absence of caveolin-1. (D) Apoptosis was determined as indicated above by PI staining followed by flow cytometry. Numerical results are mean ± s.e.m. from three independent experiments; # and § comparisons with the mock control pLacIOP, #P<0.01, §P<0.05. Vicente A. Torres et al. J Cell Sci 2006;119:1812-1823 © The Company of Biologists Limited 2006