Fig. 6 Knockdown of nestin impaired tendon repair and regeneration in a rat model of patellar tendon defect. Knockdown of nestin impaired tendon repair.

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Fig. 6 Knockdown of nestin impaired tendon repair and regeneration in a rat model of patellar tendon defect. Knockdown of nestin impaired tendon repair and regeneration in a rat model of patellar tendon defect. (A) Morphology of the repaired tissue site along the axis of the tendon in the control and nestin knockdown groups. H&E staining and polarized light microscopy images showing the collagen fibrils 2 weeks after implantation (n = 6). (B) Maturation of repaired tendon was assessed by histology scoring (n = 6). (C) H&E staining showing the histology of the junction between normal tendon and neo-tendon, as well as the midpoint of neo-tendon formation 4 weeks after implantation. Masson’s trichrome staining showing the deposited collagen at the repaired tissue site 4 weeks after implantation. Polarized light microscopy image showing the maturation of the newly formed collagen fibrils (n = 6). (D) Quantitative analyses of the collagen content. (E) Transmission electron micrographs of cross sections of collagen fibrils in the control and nestin knockdown groups from repaired tendons 4 weeks after implantation. Distribution of collagen fibril diameters of repaired tendons in the control and nestin knockdown groups 4 weeks after implantation (n = 6). (F) Biomechanical properties of the repaired tendon (failure force, energy absorbed at failure, stress at failure, and modulus) in the control and nestin knockdown groups 4 weeks after implantation (n = 6). Results are presented as means ± SD. (G) qPCR analyses showing the expression of tendon-associated genes in the repaired tendon (n = 3). Results are presented as means ± SEM. *P < 0.05, **P < 0.01 (Student’s t test). Scale bars, 100 μm (A and D); 200 nm (E). Zi Yin et al. Sci Adv 2016;2:e1600874 Copyright © 2016, The Authors