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Fig. 3. Ultrasound-mediated BMP-6 gene delivery to mini-pig tibial bone fractures. Ultrasound-mediated BMP-6 gene delivery to mini-pig tibial bone fractures.

Published byDeirdre Peters Modified over 5 years ago

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Presentation on theme: "Fig. 3. Ultrasound-mediated BMP-6 gene delivery to mini-pig tibial bone fractures. Ultrasound-mediated BMP-6 gene delivery to mini-pig tibial bone fractures."— Presentation transcript:

1 Fig. 3. Ultrasound-mediated BMP-6 gene delivery to mini-pig tibial bone fractures.
Ultrasound-mediated BMP-6 gene delivery to mini-pig tibial bone fractures. Quantitative analysis of bone formation in the tibial fractures, including (A) bone volume density (****P = ) and (B) apparent density (**P = ). Data are means ± SEM; P values were determined by one-way ANOVA with multiple comparisons. (C) Representative μCT slices of the fractures 8 weeks after surgery. Asterisks represent new bone formation within the fracture. Arrows point to cortical discontinuity indicating nonunion within the fracture. Autograft margins are represented by a dashed square. (D) Masson’s trichrome staining of tibial fractures 8 weeks after surgery at low magnification (upper subfigures) and high magnification of the yellow square (lower subfigures). Arrows point to the border between native bone and newly formed bone in the fracture. Scale bars, 1 mm. (Autograft, n = 7; BMP-6 + US, n = 8; BMP-6, n = 6; US only, n = 3; Scaffold only, n = 4; HA, hydroxyapatite.)‏ Maxim Bez et al., Sci Transl Med 2017;9:eaal3128 Published by AAAS

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