a b c d OGTT OGTT * * * Blood glucose (mg/dL) AUC (mg/dL/min) ND

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a b c d OGTT OGTT *** ** * * Blood glucose (mg/dL) AUC (mg/dL/min) ND 150 ** ND 250 HFD * 200 120 * Blood glucose (mg/dL) AUC (mg/dL/min) 150 90 100 60 50 30 60 90 120 ND HFD Time (min) c d * IPITT IPITT 80 ND ** HFD *** *** 60 150 *** Blood glucose (mg/dL) 40 100 AUC (mg/dL/min) 20 50 30 60 90 120 ND HFD Time (min) Supplemental Fig. 1. Impaired glucose tolerance and insulin sensitivity in diet-induced obese rats. Blood glucose levels (a, c) and AUC (b, d) during OGTT and IPITT in rats fed a normal diet (ND) or a high-fat diet (HFD). Statistical differences were analyzed by using one-way ANOVA followed by a Tukey’s post-hoc test or a Student’s t test, where appropriate. *P<0.05, **P<0.01 vs control rats fed a ND.