1. The gene encoding TP53INP1 is expressed in pancreatic endocrine cells A, B(A, B) Immunocytofluorescent staining of TP53INP1 (red) and insulin (green) in mouse pancreatic sections (A) and single human islet beta cell (B).
The gene encoding TP53INP1 is expressed in pancreatic endocrine cells A, B(A, B) Immunocytofluorescent staining of TP53INP1 (red) and insulin (green) in mouse pancreatic sections (A) and single human islet beta cell (B). Scale bars represent 50 μm (A) and 10 μm (B).C–EQuantitative PCR for Tp53inp1 mRNA levels in tissues and cells from rat (C) and C57BL/6J mice fed with a normal diet (5% fat; ND) or an high‐fat diet (45% fat; HFD) (D, E). Results are expressed as the mean ± SEM and are representative of two independent experiments. n = 2 for rat liver, islets and mouse spleen; n = 4 for INS‐1E cells; n = 5 for mouse exocrine pancreas; n = 6 for Min6 cells and ND and HFD islets; n = 11 for mouse islets. *P = 0.035 for HFD versus ND.
Marion Seillier et al. EMBO Mol Med. 2015;7:
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