1. Type I Interferons Interfere with Liver Glucose Metabolism
Güneş Parlakgul, Gökhan S. Hotamisligil 
Cell Metabolism 
Volume 25, Issue 6, Pages (June 2017)
DOI: /j.cmet
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2. Figure 1
Type I IFN Signaling Drives Intrahepatic CD8+ T Cell Activation and Further Metabolic Deterioration in Obesity
Chronic high-fat diet (HFD) induces CD8+ T cell expansion and activation, resulting in an increased CD8+/CD4+ ratio in liver, through type I interferon signaling. Ghazarian et al. propose an intestinal dysbiosis-liver-intrahepatic CD8+ T cell axis, which contributes to metaflammatory signaling and further disruption of insulin action in liver and impaired glucose metabolism.
Cell Metabolism  , DOI: ( /j.cmet )
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