NIHR Programme Grants for Applied Research Professor Adrian Grant Programme Director NIHR Dementia Research Workshop 14 January 2011

Programme Grants Support programmes of research rather than individual studies Individual awards for a maximum of £2m over up to five years (average of no more than £400k per year) Funding is made to an NHS Organisation in England working in collaboration with appropriate academic partners Two-stage assessment process Applications and post-award processes managed by team at the NIHR Central Commissioning Facility (NIHR CCF) Background

Programme Grants Support top quality, collaborative, multidisciplinary teams Downstream, applied research Collection of inter-related research activities Coherent stream of work, where the whole is greater than sum of the individual parts Often presented as workpackages, subdivided into discrete activities Purpose

Programme Grants Dementia care in the community Prof Steve Iliffe, Central & North West London NHS Foundation Trust Support at home through psychological and social interventions Prof Martin Orrell, North East London NHS Foundation Trust Optimizing care in care homes Prof Clive Ballard, Oxfordshire & Buckinghamshire Mental Health NHS Foundation Trust Managing challenging behaviour in dementia Prof Esme Moniz-Cook, Humber Mental Health Teaching NHS Trust Preventing acute confusional illness Prof John Young, Bradford Teaching Hospitals NHS Foundation Trust Some currently funded programmes:

Programme Grants Track record and appropriate mix of skills Relevance to priorities and needs of the NHS Likelihood of significant benefit to patients and the NHS within 3- 5 years of programmes end Quality of the proposed research Value for money Patient and Public Involvement given particular attention Selection criteria

Programme Grants Fuller details are on the website: Enquires are welcomed: The Programme Grants stand in the market place Telephone: Address:NIHR CCF Grange House 15 Church Street Twickenham, TW1 3NL Further information

NIHR Research for Patient Benefit Professor David Armstrong Programme Director NIHR Dementia Research Workshop 14 January 2011

The RfPB Programme Response-mode funding programme with a budget of £25m per year Project grants may be: Up to 36 months in duration Up to £250k Three competitions per year National Programme with ten Regional Funding Committees Open to researchers in the NHS in England

The RfPB Programme Supports high quality investigator-led research projects which have a clear trajectory into patient benefit Includes qualitative or quantitative research which: –Studies the way the NHS services are provided and used –Evaluates whether interventions are effective and provide value for money –Supports pilot or feasibility studies leading to major applications to other NIHR funding streams

The Application Process One stage application process Preliminary scrutiny and administrative sift External peer and lay review Full assessment by one of ten regional funding committees Final ratification Notification of outcome

The Scrutiny Stage Three questions will be asked: Is the proposal likely to lead to patient benefit? Is the presentation and/or methods appropriate for the research question? Is the application form completed according to the instructions described in the guidance?

Research for Patient Benefit Spend across health category ( ) Generic Health Relevance 15% Mental Health 19% Reproductive 8% Cancer 7% Oral & Gastro 7% Neurological 6% Stroke 6%

Research for Patient Benefit Essentially will use existing processes (Scrutiny Committee, scientific and lay review, Regional Funding Committee appraisal) Will alert all Regional Committees of the Call and advise them of the strategic need to fund applications in this area, subject to quality thresholds Will participate with other Programmes in cross-referring applications Dementia call

For more information, visit Or call the RfPB helpline

NIHR Evaluation Trials and Studies Programmes Professor Tom Walley, CBE Director: NIHR Evaluation Trials and Studies NIHR Dementia Research Workshop 14 January 2011

Basic Research National Institute for Health Research This pathway covers the full range of interventions - pharmaceuticals, biologicals, biotechnologies, procedures, therapies and practices - for the full range of health and health care delivery - prevention, detection, diagnosis, prognosis, treatment, care. Patient Safety and Quality Research Centres Research for Patient Benefit Programme Grants for Applied Research Health Technology Assessment Invention for Innovation Primary Care Trusts Healthcare Commissioning NHS Providers Patient Care Research for Innovation, Speculation & Creativity National Institute for Health & Clinical Excellence Guidance on Health & Healthcare NHS Institute for Innovation & Improvement Support for the NHS NHS Purchasing & Supplies Agency Centre for Evidence-based Purchasing Service Delivery & Organisation Collabs for Ldrshp in Appl Hlth Res and Care Ctr for Reviews & Dissemination, Cochrane, TARs NHS Evidence Access to Evidence Development Pathway Funding MRC Biomedical Research Units Biomedical Research Centres Public Health Research Health Services Research Strategic Health Authorities Duty of Innovation Efficacy & Mechanism Evaluation INVENTION EVALUATION ADOPTION DIFFUSION

NIHR Evaluation, Trials and Studies (NETS) programmes NETSCC: Established: 2008 Health Services Research Established: 2008 Public Health Research Established: 2008 Health Technology Assessment Established: 1993 Service Delivery & Organisation Established: 1999 Efficacy and Mechanism Evaluation Funded by the MRC Managed by NIHR Established: 2008

Efficacy and Mechanism Evaluation programme Researcher-led Types of Research Primary Research addressing efficacy +/- mechanism Who defines the question? Researcher Frequency Per year Continuous with 3 submission deadlines Purpose and Remit The EME programme is aimed at supporting science driven studies with an expectation of substantial health gain. The EME programme works seamlessly with and sits between MRC programmes and the HTA programme

NIHR Health Technology Assessment programme Purpose and Remit To deliver information about the effectiveness, costs and broader impact of healthcare treatments and tests for those who plan, provide or receive care in the NHS. Types of Research Specific technology assessment Primary research Feasibility & pilot Evidence synthesis Who defines the question? NICE Researcher Frequency Per year Direct referral to On-contract teams Primary research Evidence synthesis Theme from HTA programme Question from researcher Continuous with 4 closing dates Researcher Led Primary research Feasibility & pilot Evidence synthesis HTA programme4 calls Clinical evaluation Clinical evaluation Themed Calls 1 call NICE Guidance Commissioned

HTA Studies currently underway in dementia Reminiscence groups for people with dementia and their family care-givers Professor R Woods, University of Wales £1,536,391 HTA study of antidepressants for depression in dementia (HTA-SADD) Professor S Banerjee The Institute of Psychiatry, £2,210,588 Individual Cognitive Stimulation Therapy for dementia (iCST Trial) Professor Martin Orrell, UCL, £1,213,646

Effectiveness and cost effectiveness of Collaborative cARE for people with DEMentia in primary care (CARE-DEM trial) Professor S Iliffe, UCL £2,315,251 The START (STrAtegies for RelaTives) study: to determine the effectiveness of a manual based coping strategy programme in promoting the mental health of carers of people with dementia Professor G Livingston UCL £1,521,781 HTA Studies currently underway in dementia

NIHR Service Delivery and Organisation Programme Purpose and Remit Produces research about the organisation and delivery of healthcare for NHS leaders and decision-makers, commissioners, providers of health care, partner organisations such as local authorities and the voluntary sector, and for users of health care. This evidence is intended to improve practice in relation to the organisation and delivery of healthcare. Commissioned Researcher-led Types of Research Primary research Evidence synthesis Primary research Evidence synthesis Empirical studies Who defines the question? Researcher SDO programme Priority Areas SDO Studies Primary research Evidence synthesis Evaluations NHS SDO programme Researcher NHS Evaluations

Better mental health care for older people in general hospitals Professor J Gladman, Nottingham £473,487 SDO Studies currently underway in dementia

NIHR Public Health Research programme Purpose and Remit The PHR programme evaluates public health interventions, providing new knowledge on the benefits, costs, acceptability and wider impacts of non-NHS interventions intended to improve the health of the public and reduce inequalities in health. The scope of the programme is multi-disciplinary and broad covering a range of public health interventions. Commissioned Researcher-led Types of Research Non-NHS Primary research Evidence synthesis Non-NHS Primary research Evidence synthesis Who defines the question? Researcher PHR programme Frequency Per year Continuous with 3 closing dates As required

NIHR Health Services Research programme Purpose and Remit The HSR programme funds research to improve the quality, effectiveness and accessibility of the NHS. The HSR programme addresses the three dimensions of quality currently of central concern to the NHS: patient safety, patient experience and effectiveness of care. Types of Research Any study design Who defines the question? Researcher Frequency Per year Twice yearly Researcher-led

NETS as a system Facilitating researchers, speeding review Transfers between NETS programmes Active collaboration between programmes Directors' meetings Joint calls Meeting with networks

Keele Support for CTUs 25 (in England) now supported by HTA programme pump-priming

Major new opportunity for funding research into dementia –NETS programmes focused on projects with national reach –Multicentred –Trials and other designs (Engaging with CTUs)

For further information, please visit: NIHR Dementia Research Workshop 14 January 2011

National Institute for Health Research Dementia Research Workshop 14 January 2011