MACROMOLECULES OF LIFE Found in all living things Building blocks of all cells Made up of the atoms: Carbon, oxygen, hydrogen, Nitrogen, Phosphorus, and Sulfur There are 4 Carbohydrates  C, H, & O Lipids  C, H, & O Proteins  C, H, O, N, & S Nucleic Acids  C, H, O, N, & P

Classify each as a carbohydrate, protein or lipid. _____starch _____ long term energy storage _____ contains C, H, N and O _____ cellulose _____ enzyme _____ glycerol _____ amino acid _____ glucose _____ unsaturated fatty acid

Carbohydrates Basic units: sugars Provide energy and structural support Fiber is a carbohydrate that prevents constipation Foods: breads, cereals, vegetables, fruits, & seeds Extra glucose is converted into glycogen in the liver Glucose

Lipids/Fats Basic units: fatty acids Functions: provides energy & structure, cushions the body, and prevents heat loss Found in butter, margarine, candy made of fatty acid molecules that consist two distinct regions: a long hydrophobic hydrocarbon chain a hydrophilic head

Saturated Fats contain single carbon-to-carbon bonds has lots of hydrogen solid at room temperature (beef, pork, chicken, dairy) found in animal products Reduce Intake!  can clog blood vessels

Unsaturated Fats contain double or triple carbon-to-carbon bonds & fewer hydrogen atoms Liquid at room temperature (oils, nuts, & seeds) found in plant products Better Intake!

Molecular structures of Fats Saturated Fat Unsaturated Fat

DNA Structure discovery James Watson and Francis Crick with DNA Model in 1953.

Nucleic Acids Atoms: C, H, O, N, P Basic units: nucleotides composed of  Sugar Phosphate group Base: cytosine, guanine, adenime, thymine, uracil There are two types: DNA (deoxyribonucleic acid) RNA (ribonucleic acid) Function: DNA directs & controls all activities of all cells in an organism – RNA helps

DNA –DeoxyriboNucleic Acid DNA is the hereditary material passed on from parents to offspring Structure: double-stranded Phosphate group Sugar  deoxyribose Bases  Cytosine – Guanine Adenine – Thymine

RNA RNA helps the DNA Structure: single-stranded RiboNucleic Acid Structure: single-stranded Basic units: nucleotides Phosphate group Sugar  ribose Bases  Cytosine – Guanine Adenine – Uracil

Nitrogenous Bases

Proteins Atoms: C, H, O, N, P, S Basic units: amino acids (20) Provide energy & structure, repairs body tissues Some are called hormones, enzymes, neurotransmitters, etc. Foods high in protein: meat, eggs, poultry, milk & milk products, nuts, dried beans, peas, & lentils

Proteins Primary Structure The very basic strand of amino acids Secondary Structure The hydrogen-bond interaction among strands of amino acids giving alpha helices and beta-sheets shapes .

Proteins Interaction between alpha helices and beta-sheets. Tertiary Structure Interaction between alpha helices and beta-sheets. These protein domains for small globular proteins. Quaternary Structure Small globular proteins form protein aggregates. A famous example is hemoglobin.

Protein Structures

Protein Structures (Cont’d)

Enzymes Are proteins Speed up chemical reactions without being consumed or using energy Enzymes Amylase - breaks down sugar Proteases - break down proteins Lipases - break down lipids Catalase - breaks down hydrogen peroxide

Enzyme Action Models Models

Enzyme Action Models lock and key model  substrate & the enzyme fit together perfectly induced-fit model  Enzyme changes shape slightly to accommodate the substrate

Factors that affect enzyme action: Temperature – 37oC best for human enzymes pH – different for each enzyme 7 for amylase in the mouth 2 for pepsin in the stomach 8 for trypsin in the intestines Concentration of enzyme and substrate Coenzymes – helpers such as minerals and vitamins

Macromolecules parts of the cell Membrane