THE EMOTION AND MEMORY COMPONENTS OF THE LIMBIC SYSTEM Lab 12 THE EMOTION AND MEMORY COMPONENTS OF THE LIMBIC SYSTEM

emotional feelings and expression, includes: a) cortical part of emotion system :    anterior cingulate gyrus medial prefrontal cortex          orbitofrontal gyri    b) amygdala (key integrator and “grader” of incoming sensory information c) ventral or limbic basal ganglia : ventral striatum (nucleus accumbens) ventral pallidum (output nucleus) d) dorsomedial nucleus of thalamus e) hypothalamus - nodal point in organizing visceral & somatic emotion responses.   The emotions structures are connected by bundles of fibers that include: •  the cingulum (cortico-cortical connections) •  the ventral amygdalofugal path (VAPF) for input/output of the amygdala •  the stria terminalis (for communication of the amygdala with the septal area and hypothalamus   -   the medial forebrain bundle (MFB), the multifunctional ascending and descending tract in the lateral hypothalamus

GROSS BRAIN: EMOTION STRUCTURES

Haines 2-24 Anterior Cingulate Cortex Medial Prefrontal Cortex Anterior Cerebral Artery Medial Prefrontal Cortex Anterior Cerebral Artery Orbital frontal cortex Anterior Cerebral Artery

Haines 2-17 Orbital frontal cortex Anterior Cerebral Artery Telencephalic area of basal forebrain Diencephalic area of basal forebrain

MICROSCOPIC STRUCTURES OF THE EMOTION PART OF THE LIMBIC SYSTEM

Haines 5-36a Anterior Cingulate Cortex

Haines 5-37a Anterior Cingulate Cortex medial prefrontal cortex orbitofrontal gyri

Haines 5-35a Anterior Cingulate Cortex cingulum septum pellucidum Septal Nuclei anterior commissure hypothalamus (anterior area) Basal forebrain

Haines 5-34 ventral amygdalofugal path (VAPF) lateral hypothalamic area With medial forebrain bundle amygdala

Haines 5-31a Cingulate Gyrus cingulum dorsomedial nucleus of the thalamus cingulum stria terminalis

A NEURAL CIRCUIT FOR FEAR

Haines 4-13

Haines 4-14 Parahipocampal gyrus general area of the inferior temporal cortex

Haines 5-34 Uncus Amygdaloid nucleus

Haines 5-33 stria terminalis

Haines 5-34 ventral amygdalofugal path (VAPF) lateral hypothalamic area With medial forebrain bundle

Haines 5-35a Anterior Cingulate Cortex cingulum septum pellucidum Septal Nuclei anterior commissure Hypothalamic nuclei w/ Periventricular nuclie Basal forebrain

Haines 5-11      dorsal motor nucleus of the vagus Midrostral Medulla Level

Haines 5-20 Locus ceruleus parabrachial nucleus Rostral Pons Level

Haines 5-25 ventral tegmental area (VTA Tegmentum Rostral Midbrain Level

Haines 5-19 MainTrigeminal Motor Nucleus Rostral Pons Level Supplies muscles of mastication Rostral Pons Level

Haines 5-18 Facial motor nucleus Rostral Pons Level

Haines 5-23 Caudal Midbrain Level

MICROSCOPIC STRUCTURES: DECLARATIVE MEMORY SYSTEM

Haines 5-33 internal medullary lamina anterior nucleus of thalamus temporal (inferior) horn of lateral ventricle fimbria of fornix parahippocampal gyrus hippocampal formation alveus

Haines 5-33 body of fornix

Haines 5-32 fornix Lateral v. anterior nucleus of thalamus 3rd Mammilary body mammillothalamic tract

Haines 5-35a fornix Basal forebrain Septal Nuclei anterior commissure hypothalamus (anterior area) Basal forebrain

Haines 5-34 fornix Uncus Amygdaloid nucleus