Nonmyeloablative Unrelated Donor Hematopoietic Cell Transplantation to Treat Patients with Poor-Risk, Relapsed, or Refractory Multiple Myeloma George.

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Nonmyeloablative Unrelated Donor Hematopoietic Cell Transplantation to Treat Patients with Poor-Risk, Relapsed, or Refractory Multiple Myeloma George E. Georges, Michael B. Maris, David G. Maloney, Brenda M. Sandmaier, Mohamed L. Sorror, Judith A. Shizuru, Thoralf Lange, Edward D. Agura, Benedetto Bruno, Peter A. McSweeney, Michael A. Pulsipher, Thomas R. Chauncey, Marco Mielcarek, Barry E. Storer, Rainer Storb Biology of Blood and Marrow Transplantation Volume 13, Issue 4, Pages 423-432 (April 2007) DOI: 10.1016/j.bbmt.2006.11.011 Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Cumulative incidence of GVHD after unrelated HCT (n = 24). (A) Acute GVHD: 67% all grades of GVHD, 54% grade II, and 13% grade III GVHD by day 120. (B) Chronic extensive GVHD, 75% incidence at 3 years. (C) NRM, 21% at 3 years. Biology of Blood and Marrow Transplantation 2007 13, 423-432DOI: (10.1016/j.bbmt.2006.11.011) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 OS (solid line) and PFS (dotted line) after nonmyeloablative conditioning and unrelated HCT for (A) all patients studied (n = 24), (B) recipients of tandem autologous-unrelated HCT (n = 13), and (C) patients proceeding directly to unrelated HCT (n = 11). Biology of Blood and Marrow Transplantation 2007 13, 423-432DOI: (10.1016/j.bbmt.2006.11.011) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Risk factors for OS after nonmyeloablative conditioning and unrelated HCT for all 24 patients. (A) CCI score [15] of 0 (solid line, n = 17), or ≥ 1 (dashed line, n = 7) (P = .03). (B) Disease-sensitive (solid line, n = 7) or refractory (dashed line, n = 17) to the most recent chemotherapy regimen (P = .02). (C) Failure of previous autologous HCT (dashed line, n = 14) or no previous/no failure of previous autologous HCT (solid line, n = 10) (P = .10). Biology of Blood and Marrow Transplantation 2007 13, 423-432DOI: (10.1016/j.bbmt.2006.11.011) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions