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Reversal of Low Donor Chimerism after Hematopoietic Cell Transplantation Using Pentostatin and Donor Lymphocyte Infusion: A Prospective Phase II Multicenter.

Published byMartha Wilkinson Modified over 5 years ago

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Presentation on theme: "Reversal of Low Donor Chimerism after Hematopoietic Cell Transplantation Using Pentostatin and Donor Lymphocyte Infusion: A Prospective Phase II Multicenter."— Presentation transcript:

1 Reversal of Low Donor Chimerism after Hematopoietic Cell Transplantation Using Pentostatin and Donor Lymphocyte Infusion: A Prospective Phase II Multicenter Trial  Merav Bar, Mary E.D. Flowers, Barry E. Storer, Thomas R. Chauncey, Michael A. Pulsipher, Monica S. Thakar, Wolfgang Bethge, Rainer Storb, David G. Maloney, Brenda M. Sandmaier  Biology of Blood and Marrow Transplantation  Volume 24, Issue 2, Pages (February 2018) DOI: /j.bbmt Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Study design. Up to 20 patients could be enrolled into each study group. The enrollment to the study groups was done sequentially based on stopping rules: (i) > 15% grade IV aGVHD; (ii) < 5/10 responders. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Study treatment.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Chimerism before and after DLI.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Outcome. (A) Relapse/progression. (B) Progression-free survival. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

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