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Twenty Years of Unrelated Donor Hematopoietic Cell Transplantation for Adult Recipients Facilitated by the National Marrow Donor Program  Chatchada Karanes,

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Presentation on theme: "Twenty Years of Unrelated Donor Hematopoietic Cell Transplantation for Adult Recipients Facilitated by the National Marrow Donor Program  Chatchada Karanes,"— Presentation transcript:

1 Twenty Years of Unrelated Donor Hematopoietic Cell Transplantation for Adult Recipients Facilitated by the National Marrow Donor Program  Chatchada Karanes, Gene O. Nelson, Pintip Chitphakdithai, Edward Agura, Karen K. Ballen, Charles D. Bolan, David L. Porter, Joseph P. Uberti, Roberta J. King, Dennis L. Confer  Biology of Blood and Marrow Transplantation  Volume 14, Issue 9, Pages 8-15 (September 2008) DOI: /j.bbmt Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Number of adult transplants in the study population for each disease by transplant period. Transplant numbers for all diseases except CML have increased over the 4 time periods. Biology of Blood and Marrow Transplantation  , 8-15DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 (A) Survival of adults with AML after HCT during 4 time periods. Survival is significantly better at 2 years post-transplant for patients transplanted during compared to (P ≤ .008) and also compared to and (P < .0001). (B) Survival of adults with AML after HLA well-matched HCT during 4 time periods. Survival is significantly better (P < .0001) at 2 years post-transplant for patients transplanted during and compared to patients transplanted during and Biology of Blood and Marrow Transplantation  , 8-15DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Survival of adults with ALL after HCT during 4 time periods. Survival is significantly better (P < .0001) at 2 years posttransplant for patients transplanted during compared to patients transplanted during the previous periods. Biology of Blood and Marrow Transplantation  , 8-15DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Survival of adults with MDS after HCT during 4 time periods. Survival is significantly better (P < .0001) at 2 years post-transplant for patients transplanted during compared to patients transplanted during the previous periods. Biology of Blood and Marrow Transplantation  , 8-15DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

6 Figure 5 (A) Survival of adults with CML after HCT during 4 time periods. Survival is significantly better at 2 years post-transplant for patients transplanted during compared to patients transplanted during and (P < .0001), but was not significantly different compared to patients transplanted during (B) Survival of adults with CML in CP1, CP2/accelerated, or blast phase after HCT. Survival is significantly better (P < .0001) at 2 years post-transplant for patients transplanted during CP1 compared to the other phases. Survival is also significantly better (P < .0001) at 2 years post-transplant for patients transplanted during CP2/accelerated phase compared to blast phase. Biology of Blood and Marrow Transplantation  , 8-15DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

7 Figure 6 Survival of adults with SAA after HCT during 4 time periods. Survival is significantly better at 2 years post-transplant for patients transplanted during compared to patients transplanted during and (P < .0001), but was not significantly different compared to patients transplanted during Biology of Blood and Marrow Transplantation  , 8-15DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions


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