کزین برتر اندیشه بر نگذرد بنام خداوند جان و خرد کزین برتر اندیشه بر نگذرد

IRAN UNIVERSITY OF MEDICAL SCIENCE NEONATAL HEMATOLOGY CONGRESS Dr FARHAD CHOOBDAR NEONATALOGIST IRAN UNIVERSITY OF MEDICAL SCIENCE NEONATAL HEMATOLOGY CONGRESS

FRESH FROZEN PLASMA & CRYOPRECIPITATE

Fresh Frozen Plasma Plasma extract from Human blood Stored frozen at -18 to -30⁰c up to 1 year Thawed plasma can be stored at 1-6⁰c up to 5 days Thawed plasma should be used during 4h

Indications Deficiency of coagulation factor Liver dysfunction DIC Massive Transfusion Reversal of Warfarin effect HUS Purpura Fulminance

Not Indicated As: Volume expander Immunoglobulin replacement Nutritional support Wound healing Therapy for sepsis Instead of Factor concentrate Prophylaxy of IVH in preterms

How To Order FFP should be ABO-compatible Don’t need to be Rh-compatible Don’t need to screen for CMV or HIV Don’t need to be leukoreduced Don’t need to Irradiate

ABO selection of blood component Patient ABO type RBC & PLATELET FFP & CRYO O O,A,B,AB A A,O A,AB B B,O B,AB AB AB,A,B,O

How to infused Total infusion: Up to 10-20 ml/kg/day Infusion rate : 1-3 ml/kg/h Not to be given by long line Can be given via UVC & UAC Can be given via peripheral or central line

Complications Anaphylactic reaction in IgA deficient patients Transfusion Related Acute lung injury(TRALI) (Ab mediated) Volume overload

Cryoprecipitate Cold-insoluble precipitate Prepared from thawed FFP Re-frozen at -18⁰c Shelf life about 1 year

Cryoprecipitate Contain factors I-VIII-XIII & vWF & Fibronectin Each unit about 10-15 ml 80 units factor VIII 150 mg fibrinogen

Usage Congenital or Acquired deficiency of Fibrinogen Instead of factor VIII in emergency Deficiency of factor XIII DIC

Dosage & complication Dosage: 1 unite/5 kg Bw Same as FFP Anaphylaxis TRALI

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