1. Laura Cooling MD, MS Associate Medical Director Transfusion Medicine
Cryoprecipitate
Laura Cooling MD, MS
Associate Medical Director
Transfusion Medicine

2. Cryoprecipitate
Prepared from FFP that is allowed to thaw overnight at 4C. It is literally the “cold” precipitate” of plasma
Enriched source of Fibrinogen, VIII, vWF
Contains thrombospondin, fibronectin, some IgM antibodies

3. Cryoprecipitate Each unit 7-15 cc total volume 250 mg fibrinogen
U VIII
Adult: Pool several units (avg 10) for adults

4. Indications for Cryoprecipitate
Hypofibrinogenemia (<100 mg/dL) and bleeding/prior to surgery
Dysfibrinogenemia and bleeding/prior to surgery
Factor XIII deficiency
Fibrin patch-Oto, cardiothoracic, dental
Uremic bleeding
Less Common Now (better alternatives)
von Willebrand Disease, VIII deficiency

5. Common Mistakes Inadequate dose order 1 unit (10 cc) for adult
Inappropriate Administration
Patient with volume overload and
Multifactor deficiency (long PT/PTT)
Over-ordering/ Over transfusion
Surgery responsible for 65% cryo waste

6. Cryoprecipitate Administration
ABO compatible preferred but not required
Infused within 4 hrs of thaw, pooling
Dose: 10 pooled (adult)
1 unit/5 kg (infants/children)
Rate: Like FFP ( cc/20-30 min)
Efficacy: Increase fibrinogen 5 mg/dl /unit
10 units=raise fibrinogen 50 mg/dl