Quiescence regulators for hematopoietic stem cell June Li  Experimental Hematology  Volume 39, Issue 5, Pages 511-520 (May 2011) DOI: 10.1016/j.exphem.2011.01.008 Copyright © 2011 Terms and Conditions

Figure 1 Regulation network for HSCs quiescence. The quiescence of HSCs is tightly controlled by the regulation network, including HSC-intrinsic regulatory mechanisms and extrinsic regulatory mechanisms. Both regulatory mechanisms contain positive (→) and negative regulators (—). Among these HSC quiescence regulators that have been identified thus far, the majority are positive regulators, few are negative for the maintenance of HSCs quiescence. It appears that various positive regulators of HSC quiescence are actively restricting proliferation within the stem cell pool, and that there may exist signals in the environment to promote HSC proliferation (?). BMP = bone morphogenic proteins; SCF = stem cell factor. Experimental Hematology 2011 39, 511-520DOI: (10.1016/j.exphem.2011.01.008) Copyright © 2011 Terms and Conditions