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Maintaining Hematopoietic Stem Cells in the Vascular Niche

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1 Maintaining Hematopoietic Stem Cells in the Vascular Niche
Mark J. Kiel, Sean J. Morrison  Immunity  Volume 25, Issue 6, Pages (December 2006) DOI: /j.immuni Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 HSCs Are Maintained Adjacent to CXCL12-Expressing Reticular Cells in Vascular Niches as Well as in Other Locations, Such as at the Endosteum Most HSCs reside adjacent to sinusoids in vascular niches marked by the presence of perivascular reticular cells that express unusually large amounts of CXCL12, a chemokine that regulates the migration and maintenance of HSCs in the bone marrow. Some HSCs also reside at the endosteum or in other locations, where they are also usually present adjacent to CXCL12-expressing reticular cells. Immunity  , DOI: ( /j.immuni ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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