1. Tumor necrosis factor α in the onset and progression of leukemia
Xiaoxi Zhou, Zhuoya Li, Jianfeng Zhou 
Experimental Hematology 
Volume 45, Pages (January 2017)
DOI: /j.exphem
Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions

2. Figure 1
TNF-α mediated cell survival. The TNF-α–TNFR1–TRADD–TRAF2–RIP and tmTNF-α–TNFR2–TRAF2 complexes trigger signals leading to activation of the transcriptional factor AP-1 through activation of MAPK kinases and JNK and activation of the transcriptional factor NF-κB through the IKK complex. The tmTNF-α–TNFR2 complex also triggers signals leading to suppression of caspase 9, BAD, and FKHRL1 through activation of the PI3K–Akt pathway and promoting cell survival.
Experimental Hematology  , 17-26DOI: ( /j.exphem )
Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions

3. Figure 2
Leukemia cells cross-talk with suppressive immune cells via TNF-α and TNFRs.
Experimental Hematology  , 17-26DOI: ( /j.exphem )
Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions