1. New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells 
Mira Jeong, Margaret A. Goodell 
Experimental Hematology 
Volume 42, Issue 8, Pages (August 2014)
DOI: /j.exphem
Copyright © 2014 ISEH - International Society for Experimental Hematology Terms and Conditions

2. Figure 1
The DNA methylation and demethylation pathway. Overview of the DNA methylation and demethylation process. DNMT1 is responsible for maintenance methylation. (A) DNMT1 adds methylation to hemimethylated DNA when one strand is already methylated. DNMT3a and DNMT3b are responsible for de novo DNA methylation. They create hemimethylated CpG dinucleotides to establish new patterns of methylation. (B) Passive demethylation occurs through loss of DNMT1/3 (via loss of gene expression, gene mutation, or possibly via other mechanisms that inhibit protein function). Active demethylation is mediated by Tet-family proteins. 5mC can be hydroxylated to 5hmC by Tet proteins. 5hmC is not recognized by the maintenance methyltransferase (DNMT1), so the methylation is lost during DNA replication. In addition, 5hmC can be further oxidized to 5fCs and 5caCs and may be removed by base-excision repair in an alternate mode of active demethylation (in addition to loss of the 5hmC by cell division).
Experimental Hematology  , DOI: ( /j.exphem )
Copyright © 2014 ISEH - International Society for Experimental Hematology Terms and Conditions

3. Figure 2
Graphical representation of the dynamic methylome landscapes in various genomic regions. DNA methylation level variation across each feature is represented using colors from level 0 (blue) to 1.0 (red). Enhancer regions, CGI shores, and canyon edges represent the most differentially methylated features [38,60].
Experimental Hematology  , DOI: ( /j.exphem )
Copyright © 2014 ISEH - International Society for Experimental Hematology Terms and Conditions