Rohini Rao, BSc, Tristan R. A. Lane, MRCS, Ian J

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Presentation transcript:

Open repair versus fenestrated endovascular aneurysm repair of juxtarenal aneurysms Rohini Rao, BSc, Tristan R.A. Lane, MRCS, Ian J. Franklin, FRCS(Gen Surg), Alun H. Davies, DM, FRCS Journal of Vascular Surgery Volume 61, Issue 1, Pages 242-255.e5 (January 2015) DOI: 10.1016/j.jvs.2014.08.068 Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 1 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram. Journal of Vascular Surgery 2015 61, 242-255.e5DOI: (10.1016/j.jvs.2014.08.068) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 2 Forest plot shows the mortality rate per study with 95% confidence intervals (CIs; horizontal lines), and pooled mortality rate (represented by a diamond) for all open repair (OR) and all fenestrated endovascular aneurysm repair (FEVAR) case series combined. The odds ratio favors FEVAR but is not significant. Journal of Vascular Surgery 2015 61, 242-255.e5DOI: (10.1016/j.jvs.2014.08.068) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 3 Forest plot shows the postoperative renal insufficiency rate per study with 95% confidence intervals (CIs, horizontal lines), and pooled rate (represented by a diamond) for all open repair (OR) and all fenestrated endovascular aneurysm repair (FEVAR) case series combined. The odds ratio favors FEVAR but is not significant. Journal of Vascular Surgery 2015 61, 242-255.e5DOI: (10.1016/j.jvs.2014.08.068) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 4 Forest plot shows the postoperative permanent hemodialysis rate per study with 95% confidence intervals (CIs, horizontal lines), and pooled rate (represented by a diamond) for all open repair (OR) and all fenestrated endovascular aneurysm repair (FEVAR) case series combined. The odds ratio favors FEVAR but is not significant. Journal of Vascular Surgery 2015 61, 242-255.e5DOI: (10.1016/j.jvs.2014.08.068) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 5 Forest plots show the rate of renal failure over follow-up per study, with 95% confidence intervals (CIs, horizontal lines), and pooled rate (represented by a diamond) for all open repair and fenestrated endovascular aneurysm repair (FEVAR) case series combined. The odds ratio favors open repair and is significant. Journal of Vascular Surgery 2015 61, 242-255.e5DOI: (10.1016/j.jvs.2014.08.068) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 6 Forest plot shows the secondary intervention rate per study with 95% confidence intervals (CIs, horizontal lines), and pooled rate (represented by a diamond) for all open repair (OR) and all fenestrated endovascular aneurysm repair (FEVAR) case series combined. The odds ratio favors open repair and is significant. Journal of Vascular Surgery 2015 61, 242-255.e5DOI: (10.1016/j.jvs.2014.08.068) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 7 Hypothetical estimated Kaplan-Meier survival curves (pooled) of all patients combined from two open repair studies (Ayari,31 2001 and Knott3 2008) and five fenestrated endovascular aneurysm repair (FEVAR) studies (Beck,40 2009; Kristmundsson,42 2009; Mastracci,39 2010; Verhoeven,38 2010; and Metcalfe,36 2012). Journal of Vascular Surgery 2015 61, 242-255.e5DOI: (10.1016/j.jvs.2014.08.068) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 1 (online only) Egger funnel plot displays publication bias. The funnel plot shows the perioperative mortality rate on a logarithmic scale against the standard error for each study in the meta-analysis. The vertical line with the diamond shows the pooled estimate of the logit perioperative mortality rate in all of the studies, and the diagonal lines show the 95% confidence interval (CI) for a given standard error. Journal of Vascular Surgery 2015 61, 242-255.e5DOI: (10.1016/j.jvs.2014.08.068) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 2 (online only) Meta-regression shows the relationship between the year of study publication and the logit perioperative mortality rate of the studies. Journal of Vascular Surgery 2015 61, 242-255.e5DOI: (10.1016/j.jvs.2014.08.068) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 3 (online only) Chart outlines the perioperative mortality rates based on country of study publication. The various symbols, including triangles, crosses, and squares, represent individual studies. FEVAR, Fenestrated endovascular aneurysm repair. Journal of Vascular Surgery 2015 61, 242-255.e5DOI: (10.1016/j.jvs.2014.08.068) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 4 (online only) Meta-regression shows the relationship between study size and the logit perioperative mortality rate of the studies. FEVAR, Fenestrated endovascular aneurysm repair. Journal of Vascular Surgery 2015 61, 242-255.e5DOI: (10.1016/j.jvs.2014.08.068) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 5 (online only) Meta-regression shows the relationship between mean preoperative creatinine of the patients included in the studies and the logit perioperative mortality rate of the studies. Journal of Vascular Surgery 2015 61, 242-255.e5DOI: (10.1016/j.jvs.2014.08.068) Copyright © 2015 Society for Vascular Surgery Terms and Conditions