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A meta-analysis of anticoagulation for calf deep venous thrombosis

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Presentation on theme: "A meta-analysis of anticoagulation for calf deep venous thrombosis"— Presentation transcript:

1 A meta-analysis of anticoagulation for calf deep venous thrombosis
Randall R. De Martino, MS, MD, Jessica B. Wallaert, MD, Ana P. Rossi, MPH, MD, Alicia J. Zbehlik, MD, Bjoern Suckow, MD, Daniel B. Walsh, MD  Journal of Vascular Surgery  Volume 56, Issue 1, Pages e1 (July 2012) DOI: /j.jvs Copyright © 2012 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram of information through the phases of the systematic review of patients with isolated calf vein deep venous thrombosis (DVT). Articles excluded in full text based on failure to fulfill the inclusion criteria: (1) patients >17 years of age with venographic or duplex ultrasound-proven peroneal or tibial DVT; (2) comparative study of anticoagulation treatment vs no anticoagulation treatment for isolated calf DVT; (3) intervention group received therapeutically dosed heparin, warfarin, low-molecular-weight heparin, or fondaparinux for at least 30 days; (4) control group did not receive any therapeutic anticoagulation; (5) minimum follow-up was 30 days; and (6) article contained duplicate data as another series already included. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Rates of pulmonary embolus (PE) among treated and control patients with isolated calf vein deep venous thrombosis (DVT). CI, Confidence interval. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Rates of thrombus propagation to the popliteal vein among treated and control patients with isolated calf vein deep venous thrombosis (DVT). CI, Confidence interval. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

5 Fig 4 Mortality rates among treated and control patients with isolated calf vein deep venous thrombosis (DVT). CI, Confidence interval. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

6 Fig 5 Bleeding rates among treated and control patients with isolated calf vein deep venous thrombosis (DVT). CI, Confidence interval. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

7 Fig 6 Cochrane Risk of Bias tool for randomized controlled trials. Green (+), Low risk of bias; yellow (?), unclear from the study; red (–), high risk of bias. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

8 Fig 7 Funnel plot of studies reporting clot propagation. OR, Odds ratio. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

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