STDs Herpes genitalis & Syphilis Dominik Kralj Mentor: A. Žmegač Horvat

Herpes genitalis - ethiology HSV-2 virus, herpesviridae family neurotropic, neuroinvasive DNA virus

Primary infection acquired through sexual contact presents itself with clusters of genital sores consisting of inflamed papules and vesicles

Accompanying symptoms: pain itching burning discharge fever headache myalgia lymphadenitis malaise dysuria cervicitis proctitis reccuring infections often manifest themselves less severely

Latency

Treatment 5 x 200mg for 5 days

Syphilis caused by spirochetal bacterium Treponema pallidum known throughout history under different names (French disease, great pox, lues, Cupid’s disease) today less prevalent but still poses a problem, especially in underdeveloped countries has three stages

Primary syphilis usually through direct sexual contact appearance of a chancre at the point of exposure after three weeks a painless, firm skin ulceration which heals on its own after 4 to 6 weeks sometimes accompanied by lymphadenopathy

Secondary syphilis 1 to 6 months after primary infection

Tertiary syphilis appears following a 1atency period which lasts 1 to 10 years characterized by formation of gummas (inflammatory granulomas) other severe manifestations include cardiovascular syphilis, neurosyphilis, neuropathic joint disease

Diagnostics Treponemal -TPHA -FTA-ABS Nontreponemal -VDRL -RPR

Therapy Penicilin G 2.4 million IU (intramuscular)

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