Christopher D. Dupont, Christopher A. Hunter Immunity

Slides:

Advertisements

Similar presentations

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.

Advertisements

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,

Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells Julien Seneschal, Rachael A. Clark,

A View to a Kill: The Bacterial Type VI Secretion System Brian T. Ho, Tao G. Dong, John J. Mekalanos Cell Host & Microbe Volume 15, Issue 1, Pages 9-21.

Volume 40, Issue 1, Pages 1-2 (January 2014)

“Toll”-erance in the Skin

Volume 31, Issue 2, Pages (August 2009)

Cytokines, Skin, and Smallpox–A New Link to an Antimicrobial Peptide

Pathogen-Mediated Posttranslational Modifications: A Re-emerging Field

War on Viruses: LC3 Recruits GTPases

HIV-1 Latency by Transition

Volume 39, Issue 3, Pages (September 2013)

An Activation Marker Finds a Function

Innate and Adaptive Immunity through Autophagy

Volume 29, Issue 5, Pages (November 2008)

Autophagy Meets Phagocytosis

Chemical Proteomics of Host-Pathogen Interaction

Bacterial Reductionism: Host Thiols Enhance Virulence

Chronic Infections Capture Little Attention of the Masses

RNA Interference in Mammals: The Virus Strikes Back

Checks and Balances: IL-23 in the Intestine

RNA Interference in Mammals: The Virus Strikes Back

Vesicles Spread Susceptibility to Phages

Endosomes as Platforms for NOD-like Receptor Signaling

IL-17A Has Some Nerve! Immunity

Innate B Cells Tell ILC How It’s Done

POPsicle for Fever! Cooling Down the Inflammasome

Strength in Numbers: Visualizing CTL-Mediated Killing In Vivo

Mitchell Kronenberg, Yuki Kinjo Immunity

B. Brett Finlay, Grant McFadden Cell

Toll-like Receptor 9: AEP Takes Control

Volume 4, Issue 6, Pages (December 2008)

Intracellular Pathogens and CD8+ Dendritic Cells: Dangerous Liaisons

Who Benefits from Granulomas, Mycobacteria or Host?

“The Very Pulse of the Machine”: The Tuberculous Granuloma in Motion

Interleukin-17 Kick-Starts T Helper 1 Cell Differentiation

Chronic Infections Capture Little Attention of the Masses

Radical Host-Specific Therapies for TB

John G. Monroe, Mary E. Keir Immunity

Deconstructing Export of Malaria Proteins

Gabriel Mitchell, Ralph R. Isberg Cell Host & Microbe

Phagocytosis Immunity Volume 22, Issue 5, Pages (May 2005)

Why Worms Watch Their Hemidesmosomes and Why You Should, Too

Type III secretion system

Wenjun Ouyang, Jay K. Kolls, Yan Zheng Immunity

Salmonella’s Masterful Skill in Mast Cell Suppression

Taking Charge: Feeding Malaria via Anion Channels

From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells

Proteins in Plant Brassinosteroid Signaling

Interleukin-18 in Intestinal Inflammation: Friend and Foe?

Intrinsic Defense Mechanisms of the Intestinal Epithelium

Volume 30, Issue 2, Pages (February 2009)

Fighting for Resources: Who Started the Battle? Who Is Winning It?

Shigella Navigates Tight Corners

One Bug or Another: Promiscuous T Cells Form Lifelong Memory

Crossing the Rubicon: New Roads Lead to Host Defense

Delivering Three Punches to Knockout Intracellular Bacteria

Volume 48, Issue 4, Pages (April 2018)

Volume 10, Issue 3, Pages (September 2006)

Recycling Endosomes and TLR Signaling— The Rab11 GTPase Leads the Way

A PIP Gets the Plasmodium Protein Export Pathway Going

Matthew D. Weitzman, Jonathan B. Weitzman Cell Host & Microbe

Innate B Cells Tell ILC How It’s Done

PTENtiating CFTR for Antimicrobial Immunity

Notch 1 Keeps Pro-T cells on Track

Why Worms Watch Their Hemidesmosomes and Why You Should, Too

Marking Emerging β- and γδ-Selected T Cells

On the Road to Bacterial Cell Death

Presentation transcript:

Guanylate-Binding Proteins: Niche Recruiters for Antimicrobial Effectors Christopher D. Dupont, Christopher A. Hunter Immunity Volume 37, Issue 2, Pages 191-193 (August 2012) DOI: 10.1016/j.immuni.2012.08.005 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Mechanisms by which GBPs Mediate Immunity to Intracellular Pathogens Toxoplasma gondii actively invades host cells and resides in a specialized nonfusogenic parasitophorous vacuole (PV). GBPs are proposed to recruit IRGs, leading to the disruption of PV membrane and the killing of the parasite. In contrast, intracellular bacteria such as Mycobacteria and Listeria are phagocytosed by the host cell. GBPs are proposed to recruit autophagic machinery, antimicrobial peptides, and components of the NADPH oxidase to the phagosome. The NADPH oxidase generates reactive oxygen species, which are involved in sequestering Listeria within the phagosome and controlling bacterial infection. Immunity 2012 37, 191-193DOI: (10.1016/j.immuni.2012.08.005) Copyright © 2012 Elsevier Inc. Terms and Conditions