Saving the Ends for Last: The Role of Pol μ in DNA End Joining

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Saving the Ends for Last: The Role of Pol μ in DNA End Joining Tanya T. Paull Molecular Cell Volume 19, Issue 3, Pages 294-296 (August 2005) DOI: 10.1016/j.molcel.2005.07.008 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Proposed Structural Preferences of Mammalian Pol X Family Polymerases on Mismatched DNA Ends DNA ends with 3′ overhangs and varying lengths of alignment between the ends are shown as an example. Ends containing extensive homology (A), limited homology of 1 to 2 bp (B), no homology (C), or a single double-stranded end (D) are shown schematically with the proposed polymerase specificities shown at right. The direction of polymerization is indicated with red arrows. Template-dependent synthesis without alignment is suggested to be the activity unique to pol μ; in this case the 3′ overhang sequences are incompatible (see main text). Molecular Cell 2005 19, 294-296DOI: (10.1016/j.molcel.2005.07.008) Copyright © 2005 Elsevier Inc. Terms and Conditions