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Volume 65, Issue 6, Pages (March 2017)

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1 Volume 65, Issue 6, Pages 957-958 (March 2017)
Prokaryotic Argonaute Uses an All-in-One Mechanism to Provide Host Defense  Dipali G. Sashital  Molecular Cell  Volume 65, Issue 6, Pages (March 2017) DOI: /j.molcel Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Model for All-in-One pAgo Mechanism
Unguided pAgo preferentially chops foreign DNA, creating short dsDNA fragments. These fragments are selectively loaded based on the presence of a deoxyguanosine residue opposite the 5′ end of the guide strand. Upon binding to a chopping product, guided pAgo cleaves foreign DNA in regions specified by the guide strand. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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