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Grounded: Transcriptional Pausing in Naive mESCs

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1 Grounded: Transcriptional Pausing in Naive mESCs
Matthew G. Guenther, Richard A. Young  Cell Stem Cell  Volume 10, Issue 5, Pages (May 2012) DOI: /j.stem Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Transcriptional Differences between 2i and Serum-Grown mESCs
Schematic diagram of mESC growth conditions (top), transcriptome (middle), and RNA Polymerase II pausing differences (bottom, Pol II) in mESCs grown in 2i (left) or serum (right). Reads indicate ChIP-Seq reads. Models for lineage-specification genes are shown below the graphs in black, and start sites are indicated by an arrow. The transcriptional state of mESCs grown in either condition is readily interconverted by changing the growth media. Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2012 Elsevier Inc. Terms and Conditions


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