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Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains  Till Maurer, Ingrid E. Wertz  Molecular Cell 

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Presentation on theme: "Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains  Till Maurer, Ingrid E. Wertz  Molecular Cell "— Presentation transcript:

1 Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains  Till Maurer, Ingrid E. Wertz  Molecular Cell  Volume 63, Issue 1, Pages 4-6 (July 2016) DOI: /j.molcel Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Proposed Interactions between MINDY-1 Domains and K48-Linked Polyubiquitin The MINDY-1 catalytic domain is depicted interacting with K48-linked tri-ubiquitin, as are the tandem MIU domains. The catalytic triad is shown in red font and is positioned to cleave the distal ubiquitin moiety. Additional substrate-binding domains and substrate proteins remain to be identified. Molecular Cell  , 4-6DOI: ( /j.molcel ) Copyright © 2016 Elsevier Inc. Terms and Conditions

3 Figure 2 Deubiquitinase Cleavage Modes
Please see text for more details. Molecular Cell  , 4-6DOI: ( /j.molcel ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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