Eniko Sonkoly, MD, Anja Muller, MD, Antti I

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Presentation transcript:

IL-31: A new link between T cells and pruritus in atopic skin inflammation Eniko Sonkoly, MD, Anja Muller, MD, Antti I. Lauerma, MD, PhD, Andor Pivarcsi, PhD, Hortensia Soto, PhD, Lajos Kemeny, MD, PhD, Harri Alenius, PhD, Marie-Caroline Dieu-Nosjean, PhD, Stephan Meller, MD, Juliane Rieker, MD, Martin Steinhoff, MD, PhD, Thomas K. Hoffmann, MD, Thomas Ruzicka, MD, Albert Zlotnik, PhD, Bernhard Homey, MD Journal of Allergy and Clinical Immunology Volume 117, Issue 2, Pages 411-417 (February 2006) DOI: 10.1016/j.jaci.2005.10.033 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Quantitative real-time PCR analysis of IL-31 mRNA in healthy skin (n = 12), psoriasis (n = 24), nonlesional (n = 10) or lesional (n = 25) skin of atopic dermatitis (AD), and lesional skin (n = 5) of prurigo nodularis. Results are shown as relative units compared with 18S RNA. Measurements of individual samples and means + SDs are shown. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001, Mann-Whitney U test. Journal of Allergy and Clinical Immunology 2006 117, 411-417DOI: (10.1016/j.jaci.2005.10.033) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Regulation of IL-31 expression in atopic individuals in vivo. Quantitative real-time PCR analysis of IL-31 mRNA in skin samples of patients with atopic dermatitis (A) subjected to patch test with house dust mite allergen (n = 6) or (B) SEB (n = 6) for 0, 2, 6, and 48 hours. Results are shown as relative units compared with 18S RNA. ∗P < .05, Mann-Whitney U test. Journal of Allergy and Clinical Immunology 2006 117, 411-417DOI: (10.1016/j.jaci.2005.10.033) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Regulation of IL-31 expression in leukocytes. A-D, IL-31, CCL17, CCL26, and CXCL10 expression in peripheral blood mononuclear cells (PBMCs) treated with HSV, influenza virus, IFN-γ, SEB, or IL-4. Means + SDs of 3 donors. E, IL-31 expression in PBMCs after treatment with SEB or TSST-1 and (F) in PBMCs from healthy subjects (n = 5) and patients with atopic dermatitis (AD; n = 5) treated with IL-2, anti-CD3, or SEB. Quantitative real-time PCR analysis. Results are shown as relative units compared with 18S RNA, or as femtograms of target gene in 25 ng total cDNA. ∗P < .05; ∗∗P < .01, Mann-Whitney U test. Journal of Allergy and Clinical Immunology 2006 117, 411-417DOI: (10.1016/j.jaci.2005.10.033) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Expression pattern of OSMR (A) and IL-31RA (B) in human tissues and organs. RNA from 300 samples representing 63 tissues from 2 male and 2 female donors were processed for microarray analysis by using Affymetrix Human Genome U133 Plus 2.0 gene array. Data are expressed as relative units (average intensity values). Means + SDs are shown. Journal of Allergy and Clinical Immunology 2006 117, 411-417DOI: (10.1016/j.jaci.2005.10.033) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions