Presentation is loading. Please wait.

Presentation is loading. Please wait.

Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology  Saakshi Khattri, MD, Avner.

Published byShannon Moody Modified over 5 years ago

Similar presentations

Presentation on theme: "Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology  Saakshi Khattri, MD, Avner."— Presentation transcript:

1 Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology  Saakshi Khattri, MD, Avner Shemer, MD, Mariya Rozenblit, BA, Nikhil Dhingra, BS, Tali Czarnowicki, MD, Robert Finney, MD, Patricia Gilleaudeau, NP, Mary Sullivan-Whalen, NP, Xiuzhong Zheng, MSc, Hui Xu, MSc, Irma Cardinale, MSc, Cristina de Guzman Strong, PhD, Juana Gonzalez, PhD, Mayte Suárez-Fariñas, PhD, Jim G. Krueger, MD, PhD, Emma Guttman-Yassky, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 133, Issue 6, Pages (June 2014) DOI: /j.jaci Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Representative staining with hematoxylin and eosin (HE; A) and the proliferation marker K16 (B). All 19 lesional (LS) samples were K16 positive at week 0, and only 2 of 19 lesional samples retained positivity at week 12. Significant decreases in epidermal thickness (C), Ki67+ cell counts (D), and K16 mRNA expression (E) with CsA were shown. Values are presented as means ± SDs (Fig 1, C and D) or means ± SEMs (Fig 1, E). ***P < .001, posttreatment versus pretreatment. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Genomic differences in patients with AD before and after CsA treatment. Significant changes in differentially expressed genes defining the AD transcriptome (A) occur by week 2 in nonlesional (NL) and lesional (LS) skin (B). Heat maps are arranged by patient SCORAD scores (white-to-black gradient). Pink indicates patients with unknown SCORAD scores. Red indicates upregulated and blue indicates downregulated values. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Significant downregulation of inflammatory markers after CsA in AD skin, as quantified by using real-time PCR. A-X, Posttreatment versus pretreatment mRNA expression differences (FCHs) of selected genes, as grouped by the inflammatory pathway, in lesional and nonlesional AD skin at weeks 2 and 12 of treatment. Values are presented as means ± SEMs with posttreatment versus pretreatment P values. See Table E4 for CIs. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 A summary heat map of mRNA changes (real-time PCR) in weeks 2 and 12 lesional and nonlesional skin with FCHs (blue and red). *P < .05 and **P < .01, posttreatment versus pretreatment. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E1 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E2 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig E3 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Fig E4 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

10 Fig E5 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

11 Fig E6 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

12 Fig E7 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

13 Fig E8 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology  Saakshi Khattri, MD, Avner."

Similar presentations

Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema– dermatitis syndrome  Mirva Viljanen, MD, Emma Pohjavuori, MD, Tari.

Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema– dermatitis syndrome  Mirva Viljanen, MD, Emma Pohjavuori, MD, Tari.
Wet Wrap Therapy in Children with Moderate to Severe Atopic Dermatitis in a Multidisciplinary Treatment Program  Noreen Heer Nicol, PhD, RN, FNP, Mark.

Wet Wrap Therapy in Children with Moderate to Severe Atopic Dermatitis in a Multidisciplinary Treatment Program  Noreen Heer Nicol, PhD, RN, FNP, Mark.
Petrolatum: Barrier repair and antimicrobial responses underlying this “inert” moisturizer  Tali Czarnowicki, MD, Dana Malajian, BA, Saakshi Khattri, MD,

Petrolatum: Barrier repair and antimicrobial responses underlying this “inert” moisturizer  Tali Czarnowicki, MD, Dana Malajian, BA, Saakshi Khattri, MD,
Residual genomic profile after cyclosporine treatment may offer insights into atopic dermatitis reoccurrence  Mariya Rozenblit, BA, Mayte Suarez-Farinas,

Residual genomic profile after cyclosporine treatment may offer insights into atopic dermatitis reoccurrence  Mariya Rozenblit, BA, Mayte Suarez-Farinas,
Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis  Ana Rebane, PhD, Maya Zimmermann, PhD, Alar Aab,

Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis  Ana Rebane, PhD, Maya Zimmermann, PhD, Alar Aab,
RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications  Mayte.

RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications  Mayte.
An IL-17–dominant immune profile is shared across the major orphan forms of ichthyosis  Amy S. Paller, MD, MS, Yael Renert-Yuval, MD, Maria Suprun, MPH,

An IL-17–dominant immune profile is shared across the major orphan forms of ichthyosis  Amy S. Paller, MD, MS, Yael Renert-Yuval, MD, Maria Suprun, MPH,
Donald Y.M. Leung, MD, PhD, Emma Guttman-Yassky, MD, PhD 

Donald Y.M. Leung, MD, PhD, Emma Guttman-Yassky, MD, PhD 
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional.

Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional.
Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis  Mayte Suárez-Fariñas, PhD,

Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis  Mayte Suárez-Fariñas, PhD,
Atopic dermatitis: Age and race do matter!

Atopic dermatitis: Age and race do matter!
Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema  Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,

Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema  Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,
Inflammatory marker analysis in psoriatic skin under topical phosphodiesterase 4 inhibitor treatment  Lennart M. Roesner, PhD, Petra Kienlin, Gabriele.

Inflammatory marker analysis in psoriatic skin under topical phosphodiesterase 4 inhibitor treatment  Lennart M. Roesner, PhD, Petra Kienlin, Gabriele.
Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis  Jennifer D. Hamilton, PhD, Mayte Suárez-Fariñas,

Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis  Jennifer D. Hamilton, PhD, Mayte Suárez-Fariñas,
Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis  Julia K. Gittler, BA,

Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis  Julia K. Gittler, BA,
Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human β-defensin-3  Kevin O. Kisich, PhD, Charles.

Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human β-defensin-3  Kevin O. Kisich, PhD, Charles.
Eniko Sonkoly, MD, Anja Muller, MD, Antti I

Eniko Sonkoly, MD, Anja Muller, MD, Antti I
Relations between epidermal barrier dysregulation and Staphylococcus species– dominated microbiome dysbiosis in patients with atopic dermatitis  Can Altunbulakli,

Relations between epidermal barrier dysregulation and Staphylococcus species– dominated microbiome dysbiosis in patients with atopic dermatitis  Can Altunbulakli,
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?

Similar presentations

Ads by Google